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Art. -Nr.: HY-118606

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LDN-0044878

LDN-0044878 is a PAK3 inhibitor. LDN-0044878 inhibits the proliferation or induces the death of p53-deficient cells. LDN-0044878 exhibits moderate trypanocidal activity against Trypanosoma brucei, but does not directly inhibit the core target Rhodesain. LDN-0044878 can be used in studies related to cervical adenocarcinoma and Trypanosoma brucei infection.

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CAS. Nr.: 296246-47-4
Formel: C₂₈H₂₂N₂OS
Molecular Weight:434.56

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

LDN-0044878 Chemical Structure

CAS. Nr.: 296246-47-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

PAK3

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In Vitro

LDN-0044878 (75-150 h) reduces the viability of HeLa cells, with EC₅₀ values of 10.7 μM (75 h), 15.5 μM (100 h) and 11.1 μM (150 h)^[1].
LDN-0044878 (Compound 19) exhibits moderate trypanocidal activity, with an IC₅₀ of 14.75 against T. brucei^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 296246-47-4
Molecular Weight 434.56
Formel C₂₈H₂₂N₂OS
SMILES

N1=C(NC(C2=CC=C(SC=3C=CC=CC3)C=C2)=C1C=4C=CC=CC4)C=5C=CC(OC)=CC5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Amy Baldwin, et al. Compositions and method for inhibiting tumor growth. WO2010141738A2.

[2]. Jefferson T, et al. Screening and Identification of Inhibitors of Trypanosoma brucei Cathepsin L with Antitrypanosomal Activity. Chem Biol Drug Des. 2016;87(1):154-158. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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LDN-0044878

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