Lenercept
Lenercept (Ro 45-2081) is a recombinant fusion protein that consists of the soluble TNF-receptor (p55) linked to the Fc portion of human IgG1.
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- CAS. Nr.: 156679-34-4
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
TNFR[1]
Lenercept (TNFR-IgG; 0.8-20 μg/mouse; i.v.; once) can prevent or significantly delay endotoxin-induced lethality in mice when given prior to or shortly after endotoxin challenge[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats[1]
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Dosage:1 and 3 mg/kg
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Administration:Intraperitoneal injection, 1 h before administration of Sephadex for the 24 h study or 1 h before and at 24 and 48 h after Sephadex for the 72 h study
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Result:Inhibited the neutrophilia at 24 h after Sephadex. At 72 h after Sephadex, significantly reduced the neutrophil influx into bronchoalveolar lavage fluid (BALF) but had no inhibitory effect on eosinophil number.
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Animal Model:6- to 8-week-old female BALB/c mice, septic shock model[2]
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Dosage:0.8, 4 or 20 μg/mouse
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Administration:IV, single dose
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Result:Injection 0.5 h prior to Salmonella abortus-derived endotoxin (LD100 dose) administration prevented lethality at a dose of 20 μg per mouse and provided partial protection at lower doses. Injection of 10 μg per mouse provided significant protection 0.5 h before, 0.5 h after, or 1 h after endotoxin injection but little protection 2 h after endotoxin injection.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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[TNFRSF1A (tumor necrosis factor receptor (TNFR)superfamilly member 1A, TNFAR, TNF-RI, TNF-R-I, p55, CD120a)]2-IGHG1 Fc (Fragment constant)
ELISA, FACS, Functional assay
Chemical Information
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CAS. Nr. 156679-34-4
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SMILES
[Lenercept]
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Synonyms
p55TNF-R:Ig; Ro 45-2081; TNFR55-IgG1
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Gater PR, et al. Inhibition of Sephadex-induced lung injury in the rat by Ro 45-2081, a tumor necrosis factor receptor fusion protein. Am J Respir Cell Mol Biol. 1996 May;14(5):454-60. [Content Brief]
[2]. Ashkenazi A, et al. Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10535-9. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Lenercept Related Classifications
HY-P99692 Related Classifications
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