Art. -Nr.: HY-N7269

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Luteolin 7-diglucuronide

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Luteolin 7-diglucuronide is the major flavonoid isolated from Aloysia triphylla and Verbena officinalis.

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Reinheit: 99.34%
CAS. Nr.: 96400-45-2
Formel: C₂₇H₂₆O₁₈
Molecular Weight:638.48

Speicherung:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Luteolin 7-diglucuronide Chemical Structure

CAS. Nr.: 96400-45-2

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Luteolin 7-diglucuronide is the major flavonoid isolated from Aloysia triphylla and Verbena officinalis^[1].

Alle AMPK Isoform-spezifische Produkte anzeigen :

In Vitro

Luteolin 7-diglucuronide (5-50 µM, 24 h) inhibits the activity of protein tyrosine phosphatase 1B (PTP1B, IC₅₀=2.10 µM), upregulates the phosphorylation of AMPK, thereby inhibiting the activation of hepatic stellate cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[3]

Cell Line:

LX-2 and primary murine hepatic stellate cell
Concentration:

5-50 µM
Incubation Time:

24 h
Result:

Inhibited the expression of TGF-β1-induced HSCs activation markers such as Col-1, α-SMA and Fibronectin.

In Vivo

Luteolin 7-diglucuronide (5-40 mg/kg, ip, once daily for 5 days) exhibits protective effects against Isoproterenol (HY-B0468)-induced myocardial injury and fibrosis in mouse models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Isoproterenol-administrated mouse models^[2]
Dosage:

5-40 mg/kg
Administration:

ip, once daily for 5 days
Result:

Reduced myocardial necrosis, granulation tissue formation, and inflammatory cell infiltration.
Inhibited the expression of NADPH oxidase subunits (Cyba, Cybb, Ncf1, Ncf4 and Rac2) and ECM genes (such as Col1a1, Col1a2, Col3a1, Col12a1, Fbn1, elastin, and CTHRC1).

Chemical Information

CAS. Nr. 96400-45-2
Appearance Solid
Molecular Weight 638.48
Formel C₂₇H₂₆O₁₈
Color Yellow to brown
SMILES

O[C@@H]([C@@H]([C@@H](C(O)=O)O1)O)[C@@H](O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](C(O)=O)O2)O)O)O)[C@@H]1OC3=CC(O)=C4C(C=C(C5=CC=C(O)C(O)=C5)OC4=C3)=O
Structure Classification
- Flavonoids
- Flavones
- Phenols
- Polyphenols
Initial Source
- Plants
- other families
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (1)

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Adv Sci (Weinh)

ZFPL1 Promotes Colorectal Cancer Progression by Stabilizing ASS1 to Drive the Urea Cycle and M2 Macrophage-Mediated Metastatic Colonization. [Abstract]

2025 Dec;12(46):e05291. PMID: 41216870

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 250 mg/mL (391.55 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.5662 mL

7.8311 mL

15.6622 mL

5 mM

0.3132 mL

1.5662 mL

3.1324 mL

10 mM

0.1566 mL

0.7831 mL

1.5662 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Carnat A1, et al. Luteolin 7-diglucuronide, the major flavonoid compound from Aloysia triphylla and Verbena officinalis.Planta Med. 1995 Oct;61(5):490. [Content Brief]

[2]. Ning BB, et al., Luteolin-7-diglucuronide attenuates isoproterenol-induced myocardial injury and fibrosis in mice. Acta Pharmacol Sin. 2017 Mar;38(3):331-341. [Content Brief]

[3]. Tang BX, et al., Luteolin-7-diglucuronide, a novel PTP1B inhibitor, ameliorates hepatic stellate cell activation and liver fibrosis in mice. Acta Pharmacol Sin. 2025 Jan;46(1):122-133. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.5662 mL	7.8311 mL	15.6622 mL	39.1555 mL
	5 mM	0.3132 mL	1.5662 mL	3.1324 mL	7.8311 mL
	10 mM	0.1566 mL	0.7831 mL	1.5662 mL	3.9155 mL
	15 mM	0.1044 mL	0.5221 mL	1.0441 mL	2.6104 mL
	20 mM	0.0783 mL	0.3916 mL	0.7831 mL	1.9578 mL
	25 mM	0.0626 mL	0.3132 mL	0.6265 mL	1.5662 mL
	30 mM	0.0522 mL	0.2610 mL	0.5221 mL	1.3052 mL
	40 mM	0.0392 mL	0.1958 mL	0.3916 mL	0.9789 mL
	50 mM	0.0313 mL	0.1566 mL	0.3132 mL	0.7831 mL
	60 mM	0.0261 mL	0.1305 mL	0.2610 mL	0.6526 mL
	80 mM	0.0196 mL	0.0979 mL	0.1958 mL	0.4894 mL
	100 mM	0.0157 mL	0.0783 mL	0.1566 mL	0.3916 mL

Keywords

Luteolin 7-diglucuronide

1 Cited Publications

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Luteolin 7-diglucuronide

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Publications Citing Use of MedChemExpress (MCE) Luteolin 7-diglucuronide

Alle AMPK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Luteolin 7-diglucuronide Related Classifications

HY-N7269 Related Classifications