M3/PDE4 modulator-1
M3/PDE4 modulator-1 (compound 10f) is a bifunctional molecule that is an M3 mAChR antagonist and a PDE4 inhibitor. M3/PDE4 modulator-1 (10-1000 nM/kg; iv) reduces cysteine eosinophil influx in the OVA rat model.
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- Formel: C38H41Cl2N3O8S
- Molecular Weight:770.72
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
M3 mAChR, PDE4[1]
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Cell Line
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Type | Value | Description | References |
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| Eosinophil | ED50 |
16 nmol/Kg
Compound: 10f
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Anti-inflammatory activity against OVA-sensitized Brown-Norway rat airway inflammation model assessed as inhibition of OVA-induced eosinophil influx administered IT(Intratracheal) pretreated 24 hrs prior to OVA challenge and measured after 48 hrs by autom
Anti-inflammatory activity against OVA-sensitized Brown-Norway rat airway inflammation model assessed as inhibition of OVA-induced eosinophil influx administered IT(Intratracheal) pretreated 24 hrs prior to OVA challenge and measured after 48 hrs by autom
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[PMID: 37561958] |
| Eosinophil | ED50 |
7 nmol/Kg
Compound: 10f
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Anti-inflammatory activity against OVA-sensitized Brown-Norway rat airway inflammation model assessed as inhibition of OVA-induced eosinophil influx administered IT(Intratracheal) 2 hrs prior to OVA challenge
Anti-inflammatory activity against OVA-sensitized Brown-Norway rat airway inflammation model assessed as inhibition of OVA-induced eosinophil influx administered IT(Intratracheal) 2 hrs prior to OVA challenge
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[PMID: 37561958] |
Chemical Information
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Molecular Weight 770.72
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Formel C38H41Cl2N3O8S
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SMILES
COC1=C(OCC)C=C([C@@H](OC(C2=CC=C(CN[C@](C(O[C@H]3CN4CCC3CC4)=O)(CO)C5=CC=CC=C5)S2)=O)CC6=C(Cl)C=[N+]([O-])C=C6Cl)C=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
M3/PDE4 modulator-1 Related Classifications
HY-155819 Related Classifications
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