M3686
M3686 (Compound 29) is a potent, selective TEAD1 inhibitor with an IC50 value of 51 nM. M3686 also shows weaker binding activity on TEAD3. M3686 potently inhibits cell viability against YAP-dependent NCI-H226 cell line with an IC50 value of 0.06 uM. M3686 shows strong anti-tumor effects in the NCI-H226 xenograft model.
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- CAS. Nr.: 2738550-24-6
- Formel: C21H18F3N5O2
- Molecular Weight:429.40
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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TEAD1 51 nM (IC50) |
Chemical Information
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CAS. Nr. 2738550-24-6
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Molecular Weight 429.40
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Formel C21H18F3N5O2
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SMILES
O[C@@H]1CN(C(C2=CC3=C(N(C4=CC=C(C(F)(F)F)C=C4)C5=NN(C)N=C53)C=C2)=O)CC1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
M3686 Related Classifications
HY-170764 Related Classifications
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