Pichromene
Based on 1 Customer Validation
Pichromene (S14161) is an anticancer agent and weak PI3K inhibitor. Pichromene can effectively inhibit tumor growth in leukemia mouse models and can be used in cancer research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.0%
- CAS. Nr.: 883046-50-2
- Formel: C17H14FNO4
- Molecular Weight:315.30
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Speicherung:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16 | GI50 |
23.28 μM
Compound: 2, S14161
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Cytotoxicity against mouse B16 cells after 24 to 72 hrs by SRB assay
Cytotoxicity against mouse B16 cells after 24 to 72 hrs by SRB assay
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[PMID: 23601711] |
| K562 | GI50 |
1.24 μM
Compound: 2, S14161
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Cytotoxicity against human K562 cells after 24 to 72 hrs by SRB assay
Cytotoxicity against human K562 cells after 24 to 72 hrs by SRB assay
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[PMID: 23601711] |
| LP-1 | GI50 |
0.57 μM
Compound: 2, S14161
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Cytotoxicity against human LP-1 cells after 24 to 72 hrs by SRB assay
Cytotoxicity against human LP-1 cells after 24 to 72 hrs by SRB assay
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[PMID: 23601711] |
| MDA-MB-231 | GI50 |
8.53 μM
Compound: 2, S14161
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Cytotoxicity against human MDA-MB-231 cells after 24 to 72 hrs by SRB assay
Cytotoxicity against human MDA-MB-231 cells after 24 to 72 hrs by SRB assay
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[PMID: 23601711] |
| Platelet | IC50 |
3.79 μM
Compound: S14161
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Inhibition of collagen-induced platelet aggregation in human platelet rich plasma preincubated for 10 mins followed by collagen addition by aggregometric method
Inhibition of collagen-induced platelet aggregation in human platelet rich plasma preincubated for 10 mins followed by collagen addition by aggregometric method
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[PMID: 27996269] |
| U-87MG ATCC | GI50 |
18.72 μM
Compound: 2, S14161
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Cytotoxicity against human U87 cells after 24 to 72 hrs by SRB assay
Cytotoxicity against human U87 cells after 24 to 72 hrs by SRB assay
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[PMID: 23601711] |
Chemical Information
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CAS. Nr. 883046-50-2
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Appearance Solid
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Molecular Weight 315.30
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Formel C17H14FNO4
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Color Off-white to light yellow
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SMILES
O=[N+](C1=CC2=CC=CC(OCC)=C2OC1C3=CC=C(F)C=C3)[O-]
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Synonyms
S14161
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Mao X, et al. A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway. Blood. 2011 Feb 10;117(6):1986-97. [Content Brief]
[2]. Fouqué A, et al. A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells. J Med Chem. 2015 Aug 27;58(16):6559-73. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Pichromene Related Classifications
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