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Art. -Nr.: HY-106434

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Piritrexim

(Synonyms: BW 301U; NSC 351521)

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Piritrexim (BW 301U) is a potent dihydrofolate reductase (DHFR) inhibitor against Pneumocystis carinii and Toxoplasma gondii, with IC₅₀ values of 0.038 and 0.011 μM, respectively. Piritrexim can be used for acquired immune deficiency syndrome (AIDS) research. Piritrexim also is an anticancer agent.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.07%
CAS. Nr.: 72732-56-0
Formel: C₁₇H₁₉N₅O₂
Molecular Weight:325.37

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Piritrexim Chemical Structure

CAS. Nr.: 72732-56-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- Clinical Trial
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	24 nM Compound: PTX	Cytotoxic activity evaluated against A549 tumor cells Cytotoxic activity evaluated against A549 tumor cells	[PMID: 8632413]
CCRF S-180	ED₅₀	0.012 μM Compound: BW-301U	Cytotoxic activity against the S180 cell cultures Cytotoxic activity against the S180 cell cultures	[PMID: 6928967]
CCRF-CEM	IC₅₀	0.013 μM Compound: 5	Concentration causing inhibition of CCRF-CEM human leukemic lymphoblasts growth in a 72 hr culture Concentration causing inhibition of CCRF-CEM human leukemic lymphoblasts growth in a 72 hr culture	[PMID: 15974594]
D54 cell line	IC₅₀	230 nM Compound: PTX	Cytotoxic Activity was evaluated against D54 tumor cells Cytotoxic Activity was evaluated against D54 tumor cells	[PMID: 8632413]
Daoy	IC₅₀	70 nM Compound: PTX	Cytotoxic activity was evaluated against Daoy tumor cells Cytotoxic activity was evaluated against Daoy tumor cells	[PMID: 8632413]
HCT-8	IC₅₀	68 nM Compound: PTX	Cytotoxic Activity was evaluated against HCT-8 tumor cells Cytotoxic Activity was evaluated against HCT-8 tumor cells	[PMID: 8632413]
L1210	ED₅₀	0.002 μM Compound: BW-301U	Cytotoxic activity against the L1210 cell cultures Cytotoxic activity against the L1210 cell cultures	[PMID: 6928967]
NCI-H460	IC₅₀	260 nM Compound: PTX	Cytotoxic Activity was evaluated against H460 tumor cells Cytotoxic Activity was evaluated against H460 tumor cells	[PMID: 8632413]
P388	IC₅₀	21 nM Compound: PTX	Cytotoxic activity was evaluated against P388D1 tumor cells Cytotoxic activity was evaluated against P388D1 tumor cells	[PMID: 8632413]
U-373MG ATCC	IC₅₀	55 nM Compound: PTX	Cytotoxic activity was evaluated against U373MG tumor cells Cytotoxic activity was evaluated against U373MG tumor cells	[PMID: 8632413]
U-87MG ATCC	IC₅₀	48 nM Compound: PTX	Cytotoxic activity was evaluated against U87MG tumor cells Cytotoxic activity was evaluated against U87MG tumor cells	[PMID: 8632413]
Vero	IC₅₀	30 nM Compound: PTX	Cytotoxic Activity was evaluated against Vero tumor cells Cytotoxic Activity was evaluated against Vero tumor cells	[PMID: 8632413]
W256	ED₅₀	0.008 μM Compound: BW-301U	Cytotoxic activity against the Walker 256 carcinosarcoma in rats Cytotoxic activity against the Walker 256 carcinosarcoma in rats	[PMID: 6928967]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 72732-56-0
Appearance Solid
Molecular Weight 325.37
Formel C₁₇H₁₉N₅O₂
Color Off-white to light yellow
SMILES

CC1=C(CC2=C(C=CC(OC)=C2)OC)C=NC3=NC(N)=NC(N)=C13
Synonyms

BW 301U; NSC 351521
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Rosowsky A, et al. 2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. J Med Chem. 1993 Oct 15;36(21):3103-12. [Content Brief]

[2]. Zink M, et al. Structural variations of piritrexim, a lipophilic inhibitor of human dihydrofolate reductase: synthesis, antitumor activity and molecular modeling investigations. Eur J Med Chem. 2004 Dec;39(12):1079-88. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
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Piritrexim

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Piritrexim Related Classifications

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