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Art. -Nr.: HY-181071

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POLRMT-IN-3

POLRMT-IN-3 is a photosensitive inhibitor of mitochondrial RNA polymerase (POLRMT). POLRMT-IN-3 is biologically inactive in the dark but rapidly releases the active parent compound LJ03 upon illumination with 405 nm light, enabling spatiotemporally precise inhibition of POLRMT. POLRMT-IN-3 exhibits antitumor activity and can be used in research on tumors such as pancreatic cancer and ovarian cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₃₆H₃₀FN₃O₇
Molecular Weight:635.64

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

POLRMT-IN-3 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

RNA Polymerase

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In Vitro

POLRMT-IN-3 (Compound J5) (168 h) exhibits low antiproliferative activity against MIA PaCa-2 and HEK293T cells under dark conditions, with IC₅₀ values of 9.900 μM and 7.358 μM, respectively^[1].
POLRMT-IN-3 significantly suppresses the transcription levels of ND1, CytB, and COX1, as well as the protein levels of NDUFB8, UQCRC2, and MTCO1 in MIA PaCa-2 cells after 3 minutes of 405 nm light irradiation^[1].
POLRMT-IN-3 (25-100 nM; 14 days) followed by 405 nm irradiation for 3 minutes exhibits a dose-dependent inhibitory effect on colony formation in MIA PaCa-2 cells ^[1].
POLRMT-IN-3 exhibits photo-dependent antiproliferative activity in A2780, HeLa, A431, MDA-MB-468, and HepG2 cells after 3 minutes of 405 nm light irradiation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

POLRMT-IN-3 (200-500 nM; aqueous exposure; 3 days) exhibits irradiation-dependent and dose-dependent inhibition of MIA PaCa-2 tumors in a zebrafish xenograft model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Zebrafish (AB strain) treated CM-DiI labeled MIA PaCa-2 cells^[1]
Dosage:

200 nM; 500 nM
Administration:

Aqueous exposure; followed by 3 min of 405 nm irradiation; 3 days
Result:

Showed no effect on tumor proliferation under dark conditions.
Elicited dose-dependent suppression of tumor growth with no apparent toxicity after 405 nm light irradiation for 3 min.

Chemical Information

Molecular Weight 635.64
Formel C₃₆H₃₀FN₃O₇
SMILES

O=C1C=C(C2=CC=CC=C2C)C3=C(O1)C=C(O[C@H](C)C(N4CCN(CC5=C([N+]([O-])=O)C=C6OC7=CC=CC=C7C6=C5)CC4)=O)C(F)=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Huang L, et al. A photoactivatable prodrug strategy toward spatially targeted inhibition of POLRMT for anticancer therapy. Eur J Med Chem. 2026;304:118537. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
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POLRMT-IN-3

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

POLRMT-IN-3 Related Classifications

HY-181071 Related Classifications