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Art. -Nr.: HY-150081

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PRMT5-IN-21

PRMT5-IN-21 (compound 1) is a potent cyclonucleoside PRMT5 inhibitor.

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CAS. Nr.: 2922673-38-7
Formel: C₁₈H₁₈F₂N₆O₃
Molecular Weight:404.37

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

PRMT5-IN-21 Chemical Structure

CAS. Nr.: 2922673-38-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

PRMT5-IN-21 (compound 1) is a potent cyclonucleoside PRMT5 inhibitor^[1].

IC₅₀ & Target

PRMT5

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
Sf21	IC₅₀	5.7 μM Compound: 1	Inhibition of full-length (FL)-PRMT5:MEP50 enzyme complex (unknown origin) expressed in Sf21 cells assessed as reduction in methylation activity using the N-terminus of H4 histone derived substrate peptide H4R3(Me1) by PRMT5:MEP50 biochemical assay Inhibition of full-length (FL)-PRMT5:MEP50 enzyme complex (unknown origin) expressed in Sf21 cells assessed as reduction in methylation activity using the N-terminus of H4 histone derived substrate peptide H4R3(Me1) by PRMT5:MEP50 biochemical assay	[PMID: 35594650]

Chemical Information

CAS. Nr. 2922673-38-7
Molecular Weight 404.37
Formel C₁₈H₁₈F₂N₆O₃
SMILES

FC1=C(F)C=CC([C@@H]2[C@@H]3[C@@H](O)[C@@H](O)[C@H](N4C(N=CN=C5N)=C5N=C4NCC2)O3)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kawamura S, et al. Design and synthesis of unprecedented 9- and 10-membered cyclonucleosides with PRMT5 inhibitory activity. Bioorg Med Chem. 2022 Jul 15;66:116820. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
Verweise

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PRMT5-IN-21

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

PRMT5-IN-21 Related Classifications

HY-150081 Related Classifications