CD27
CD27 (TNFRSF7) is a constitutive co-stimulatory TNF receptor superfamily member expressed on naive and memory T cells, B-cell subsets and NK cells, upregulated upon activation. CD27 is a disulfide-linked homodimeric type I transmembrane glycoprotein whose cytoplasmic tail binds TRAF2/TRAF5, activating canonical NF-κB, JNK and p38 pathways downstream of its ligand CD70 (CD27L, TNFSF7). CD27 co-stimulation complements CD28 by sustaining T-cell proliferation, survival and differentiation, promoting memory precursor formation and Th1 commitment, enhancing B-cell germinal center responses and immunoglobulin production, and amplifying NK-cell cytotoxicity. CD27-CD70 interaction is critical for antiviral CD8+ T-cell responses, particularly for resolving chronic lymphocytic choriomeningitis virus infection. Aberrant CD70 expression on tumor and stromal cells drives T-cell exhaustion through chronic CD27 engagement and supports Hodgkin lymphoma and renal carcinoma immune escape, while CD27 agonism (varlilumab) and CD70-targeting agents (CAR-T, antibody-drug conjugates) are advancing in cancer immunotherapy.
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CD27 Recombinant Proteins (14)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
