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Art. -Nr.: HY-12866B

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(R)-Larotrectinib

Name: (R)-Larotrectinib
Brand: MedChemExpress
SKU: HY-12866B
Availability: PreOrder

(Synonyms: (R)-LOXO-101; (R)-ARRY-470)

(R)-Larotrectinib is a potent TRK inhibitor with an IC₅₀ value of 28.5 nM for TrkA. (R)-Larotrectinib can be used for researching cancer, inflammatory and certain infectious diseases

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1223404-68-9
Formel: C₂₁H₂₂F₂N₆O₂
Molecular Weight:428.44

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

(R)-Larotrectinib Chemical Structure

CAS. Nr.: 1223404-68-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

(R)-Larotrectinib is a potent TRK inhibitor with an IC₅₀ value of 28.5 nM for TrkA. (R)-Larotrectinib can be used for researching cancer, inflammatory and certain infectious diseases^[1]

IC₅₀ & Target

TrkA

28.5 nM (IC₅₀)

Alle Trk Receptor Isoform-spezifische Produkte anzeigen :

Chemical Information

CAS. Nr. 1223404-68-9
Molecular Weight 428.44
Formel C₂₁H₂₂F₂N₆O₂
SMILES

O=C(N1C[C@H](O)CC1)NC2=C3N=C(N4[C@@H](C5=CC(F)=CC=C5F)CCC4)C=CN3N=C2
Synonyms

(R)-LOXO-101; (R)-ARRY-470
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Julia Haas, et al. SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS. WO2010048314A1 (compound 93)

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Protokoll
Reinheit & Dokumentation
Verweise

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(R)-Larotrectinib

Alle Trk Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

Chemical Information

Protokoll

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

(R)-Larotrectinib Related Classifications

HY-12866B Related Classifications

Bioz

Keywords

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