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Art. -Nr.: HY-123866

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RO-2443

RO-2443 is a dual MDM2/MDMX-p53 antagonist with an IC₅₀ value of 33 nM for MDM2 and an IC₅₀ value of 41 nM for MDMX. RO-2443 binds to the ZMP domain of ZMP-RNase L, inducing its dimerization. RO-2443 can be used for research on cancer and innate immune responses.

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CAS. Nr.: 1416663-79-0
Formel: C₂₀H₁₄ClF₂N₃O₂
Molecular Weight:401.80

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

RO-2443 Chemical Structure

CAS. Nr.: 1416663-79-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
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Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

MDMX

41 nM (IC₅₀)

MDM2

33 nM (IC₅₀)

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

In Vitro

RO-2443 binds MDMX and MDM2 with IC₅₀ values of 41 nM and 33 nM, respectively, in biochemical binding assays^[1].
RO-2443 is a dual p53-MDM2/p53-MDMX antagonist with IC₅₀ values of 33 nM for MDM2 and 41 nM for MDMX in cell-free binding assays^[2].
RO-2443 binds the MDMX p53-interaction domain with K_D 78 nM and induces its dimerization^[3].
RO-2443 is a dual MDM2/MDMX-p53 binding inhibitor with IC₅₀ values of 33 nM for MDM2 and 41 nM for MDMX in a cell-free TR-FRET assay^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1416663-79-0
Molecular Weight 401.80
Formel C₂₀H₁₄ClF₂N₃O₂
SMILES

C(C=1C=2C(=C(C)C(Cl)=CC2)NC1)=C3C(=O)N(CC4=CC(F)=C(F)C=C4)C(=O)N3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Zhao Y, et al. Small molecule inhibitors of MDM2-p53 and MDMX-p53 interactions as new cancer therapeutics[J]. BioDiscovery, 2013, 8: e8950.

[2]. Graves B, et al. Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization. Proceedings of the National Academy of Sciences of the United States of America. 2012 Jul 17;109(29):11788-93. [Content Brief]

[3]. Garvie CW, et al. Mechanistic insights into RNase L through use of an MDMX-derived multi-functional protein domain. Biochimica et biophysica acta. 2013 Aug;1834(8):1562-71.

[4]. Zhang Q, et al. Targeting p53-MDM2-MDMX loop for cancer therapy. Sub-cellular biochemistry. 2014;85:281-319. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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- In Vitro
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RO-2443

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

In Vitro

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

RO-2443 Related Classifications

HY-123866 Related Classifications

Bioz

Keywords

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