S-Methoprene
Based on 2 publication(s) in Google Scholar
S-Methoprene is an insect juvenile hormone analog and effective insecticide that blocks the transition from pupa to adult. S-Methoprene is also a CB(1) receptor ligand and inhibits the binding of the CB1 receptor antagonist [3H]CP-55940 to the CB1 receptor (IC50: 19.31 μM).
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- Reinheit: 99.25%
- CAS. Nr.: 65733-16-6
- Formel: C19H34O3
- Molecular Weight:310.47
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Speicherung:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Publications Citing Use of MedChemExpress (MCE) S-Methoprene
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Biologische Aktivität
CB1 receptor[2]
PMSF (HY-B0496) inhibits [3H]CP-55940 binding to mouse meninges. S-Methoprene (4 μM) inhibits [3H]CP-55940 binding by 27.32± 4.11% and 28.16± 4.17% in the absence and presence of 50 μM PMSF, respectively[2].
S-Methoprene also inhibits CP-55940-stimulated binding of [35S]GTPγS to mouse meninges. S-Methoprene inhibits CB1 receptor binding in a concentration-dependent manner with Ki of 2.13 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 65733-16-6
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Appearance Liquid (Density: 0.913 g/ml)
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Molecular Weight 310.47
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Formel C19H34O3
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Color Colorless to light yellow
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SMILES
CC(C)(OC)CCC[C@H](C)C/C=C/C(C)=C/C(OC(C)C)=O
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Synonyms
(+)-Methoprene; (7S)-Methoprene
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Pestic Biochem Physiol
The role of 20-hydroxyecdysone and juvenile hormone in insecticidal activity of Bacillus thuringiensis regulated by DUOX-ROS immunity in Spodoptera exigua. [Abstract]2025 Mar:208:106222. PMID: 40015833 -
Pestic Biochem Physiol
Juvenile hormone inhibits lipogenesis of Spodoptera exigua to response to Bacillus thuringiensis GS57 infection. [Abstract]2024 Nov:205:106110. PMID: 39477628
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (322.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.05 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (8.05 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (269 KB)
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SDS (394 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Adnan SM, et al. Accelerated Sexual Maturation in Methoprene-Treated Sterile and Fertile Male Queensland Fruit Flies (Diptera: Tephritidae), and Mosquito Larvicide as an Economical and Effective Source of Methoprene. J Econ Entomol. 2019 Dec 9;112(6):2842-2849. [Content Brief]
[2]. Dhopeshwarkar AS, et al. The actions of benzophenanthridine alkaloids, piperonyl butoxide and (S)-methoprene at the G-protein coupled cannabinoid CB₁ receptor in vitro. Eur J Pharmacol. 2011 Mar 1;654(1):26-32. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2209 mL | 16.1046 mL | 32.2092 mL | 80.5231 mL |
| 5 mM | 0.6442 mL | 3.2209 mL | 6.4418 mL | 16.1046 mL | |
| 10 mM | 0.3221 mL | 1.6105 mL | 3.2209 mL | 8.0523 mL | |
| 15 mM | 0.2147 mL | 1.0736 mL | 2.1473 mL | 5.3682 mL | |
| 20 mM | 0.1610 mL | 0.8052 mL | 1.6105 mL | 4.0262 mL | |
| 25 mM | 0.1288 mL | 0.6442 mL | 1.2884 mL | 3.2209 mL | |
| 30 mM | 0.1074 mL | 0.5368 mL | 1.0736 mL | 2.6841 mL | |
| 40 mM | 0.0805 mL | 0.4026 mL | 0.8052 mL | 2.0131 mL | |
| 50 mM | 0.0644 mL | 0.3221 mL | 0.6442 mL | 1.6105 mL | |
| 60 mM | 0.0537 mL | 0.2684 mL | 0.5368 mL | 1.3421 mL | |
| 80 mM | 0.0403 mL | 0.2013 mL | 0.4026 mL | 1.0065 mL | |
| 100 mM | 0.0322 mL | 0.1610 mL | 0.3221 mL | 0.8052 mL |
S-Methoprene Related Classifications
HY-B1161A Related Classifications
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