STAT3-IN-17
Based on 1 Customer Validation
STAT3-IN-17 is a moderate STAT3 inhibitor (IC50=0.7 μM; HEK-Blue IL-6), with antiproliferative activity in HeLa cells. STAT3-IN-17 has good pharmacokinetic characteristics. STAT3-IN-17 also inhibits pyruvate-ferredoxin oxidoreductase (PFOR), and inhibits Helicobacter pylori.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.0%
- CAS. Nr.: 1245814-52-1
- Formel: C11H6F3N3O3S
- Molecular Weight:317.24
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Chemical Information
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Biologische Aktivität
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STAT3 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
3 μM
Compound: 15
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Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
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[PMID: 34055214] |
| Caco-2 | IC50 |
1.8 μM
Compound: 15
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Antiproliferative activity against human Caco-2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human Caco-2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
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[PMID: 34055214] |
| HeLa | IC50 |
1.8 μM
Compound: 15
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Antiproliferative activity against human HeLa cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
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[PMID: 34055214] |
| HeLa | IC50 |
2.7 μM
Compound: 15
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Cytotoxicity against human HeLa cells assessed as inhibition of cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as inhibition of cell viability measured after 48 hrs by MTT assay
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[PMID: 34055214] |
| HL-60 | IC50 |
1.2 μM
Compound: 15
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Antiproliferative activity against human HL60 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human HL60 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
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[PMID: 34055214] |
| HT-29 | IC50 |
>10 μM
Compound: 15
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Antiproliferative activity against human HT29 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human HT29 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
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[PMID: 34055214] |
| PC-3 | IC50 |
>10 μM
Compound: 15
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Antiproliferative activity against human PC3 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
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[PMID: 34055214] |
STAT3-IN-17 (compound 15) (10 μM; 20 h, 48 h) inhibits STAT3 pathway with inhibition rate of 76.5%, and also inhibits HEK-Blue IL-6 cells viability to 15%[1].
STAT3-IN-17 (2.5-40 μM; 24 h) inhibits the phosphorylation of STAT3 (Y705)[1].
STAT3-IN-17 (10 μM, 50 μM; 48 h) inhibits HEK 293T cell growth, as well as inhibiting HeLa cell growth with an IC50 value of 2.7 μM[1].
(D)-PPA 1 (compound 24) inhibits microorganisms Helicobacter pylori and Campylobacter jejuni with MIC values of 1.6 μM and 4.7 μM, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1245814-52-1
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Appearance Solid
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Molecular Weight 317.24
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Formel C11H6F3N3O3S
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Color Light yellow to yellow
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SMILES
O=C(NC1=NC=C([N+]([O-])=O)S1)C2=CC=C(C(F)(F)F)C=C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 25 mg/mL (78.80 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1522 mL | 15.7609 mL | 31.5219 mL | 78.8047 mL |
| 5 mM | 0.6304 mL | 3.1522 mL | 6.3044 mL | 15.7609 mL | |
| 10 mM | 0.3152 mL | 1.5761 mL | 3.1522 mL | 7.8805 mL | |
| 15 mM | 0.2101 mL | 1.0507 mL | 2.1015 mL | 5.2536 mL | |
| 20 mM | 0.1576 mL | 0.7880 mL | 1.5761 mL | 3.9402 mL | |
| 25 mM | 0.1261 mL | 0.6304 mL | 1.2609 mL | 3.1522 mL | |
| 30 mM | 0.1051 mL | 0.5254 mL | 1.0507 mL | 2.6268 mL | |
| 40 mM | 0.0788 mL | 0.3940 mL | 0.7880 mL | 1.9701 mL | |
| 50 mM | 0.0630 mL | 0.3152 mL | 0.6304 mL | 1.5761 mL | |
| 60 mM | 0.0525 mL | 0.2627 mL | 0.5254 mL | 1.3134 mL |
STAT3-IN-17 Related Classifications
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