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Art. -Nr.: HY-122903S

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TK216-d₄

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TK216-d₄ is the deuterium labeled TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor. TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity.

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Reinheit: 98.52%
CAS. Nr.: 3034816-36-6
Formel: C₁₉H₁₁D₄Cl₂NO₃
Molecular Weight:380.26

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

TK216-d₄ Chemical Structure

CAS. Nr.: 3034816-36-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- Anwendung
Chemical Information
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Bioz

Biologische Aktivität

Beschreibung

TK216-d₄ is the deuterium labeled TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor^[1]. TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity^[2].

IC₅₀ & Target

Helicase

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anwendung

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS. Nr. 3034816-36-6
Unlabeled Cas 1903783-48-1
Appearance Solid
Molecular Weight 380.26
Formel C₁₉H₁₁D₄Cl₂NO₃
Color White to off-white
SMILES

O=C1NC2=C(C1(O)CC(C3=C([2H])C([2H])=C(C([2H])=C3[2H])C4CC4)=O)C(Cl)=CC=C2Cl
Versand

Room temperature in continental US; may vary elsewhere.