TPP-9476
TPP-9476 (BAY-943 antibody) is an anti-human IL3RA (CD123) monoclonal antibody with human IL3RA Kd of 11 nM and cynomolgus monkey IL3RA Kd of 16 nM. TPP-9476 binds specifically to human and cynomolgus monkey IL3RA, undergoes target-dependent internalization into lysosomes of IL3RA-positive cells.TPP-9476 exerts antiproliferative effects in IL3RA-expressing acute myeloid leukemia and classical Hodgkin lymphoma cells, reduces tumor burden, improves survival, and induces complete tumor remission in relevant xenograft mouse models.
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Human
TPP-9476 (IL3RA-targeting antibody) (titrated log M values) binds with high affinity to recombinant human and cynomolgus monkey IL3RA protein, and shows specific, dose-dependent binding to IL3RA-positive human acute myeloid leukemia cell lines MV-4-11, MOLM-13, and KG-1, with no binding to murine IL3RA[1].
TPP-9476 (IL3RA-targeting antibody) (10-20 μg/mL; 0-6 h) undergoes specific, time-dependent internalization into IL3RA-positive MOLM-13 and MV-4-11 acute myeloid leukemia cells, and colocalizes with lysosomes in MOLM-13 cells but not IL3RA-negative HBL-1 cells[1].
TPP-9476 (IL3RA-targeting antibody) (up to 3.00×10-7 M; 72 h) alone has no antiproliferative activity in IL3RA-positive human acute myeloid leukemia and Hodgkin lymphoma cell lines, even at concentrations up to 3.00×10-7 M after 72 h incubation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MV-4-11, MOLM-13, HDLM-2, THP-1, NCI-H292
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Concentration:Up to 3.00 × 10-7 M
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Incubation Time:72 h
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Result:Showed no antiproliferative activity (IC50 > 3.00 × 10-7 M) in IL3RA-positive MV-4-11, MOLM-13, HDLM-2, THP-1, and IL3RA-low NCI-H292 cell lines.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
IL-3Ra/CD123
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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ELISA, FACS, Functional assay
Chemical Information
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SMILES
[TPP-9476]
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Synonyms
BAY-943 antibody
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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