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Art. -Nr.: HY-169136

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U-99363E

U-99363E is a selective dopamine D4 receptor antagonist with a K_i value of 2.2 nM. U-99363E exhibits at least 100-fold lower affinity for other dopaminergic, serotonergic and adrenergic receptors. U-99363E can be used in studies related to selective dopamine D4 site labeling or blockade.

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CAS. Nr.: 170856-57-2
Formel: C₂₀H₂₇N₃O
Molecular Weight:325.45

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

U-99363E Chemical Structure

CAS. Nr.: 170856-57-2

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
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Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

Human D₄ Receptor

2.2 nM (Ki)

Alle Dopamine Receptor Isoform-spezifische Produkte anzeigen :

Alle 17β-HSD Isoform-spezifische Produkte anzeigen :

17β-HSD5/AKR1C3

In Vitro

U-99363E (1 μM; 16-18 h) antagonizes Quinpirole (HY-B1752)-induced mitogenesis in Chinese hamster ovary cells expressing the human dopamine D₄ receptor^[1].
U-99363E (1 μM; 1 h) binds with high affinity (K_i = 2.2 nM) and 126-fold selectivity to human dopamine D₄ receptors (expressed in human embryonic kidney cell membranes) over rat D₂_i dopamine receptors, and exhibits at least 100-fold lower affinity for other tested dopaminergic, serotonergic, and adrenergic receptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 170856-57-2
Molecular Weight 325.45
Formel C₂₀H₂₇N₃O
SMILES

CCOC1=CC=CN=C1N(C2CCN(CC2)CC3=CC=CC=C3)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Schlachter SK, et al. Substituted 4-aminopiperidines having high in vitro affinity and selectivity for the cloned human dopamine D4 receptor. European journal of pharmacology. 1997 Mar 19;322(2-3):283-6.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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U-99363E

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