U-19052
U-19052 is a selective competitive peptidoleukotriene D/E receptor antagonist. U-19052 acts as a reversible antagonist that not affecting responses to non-leukotriene agonists. U-19052 does not exhibit agonist activity or induce contraction in guinea pig tracheal or ileal strips. U-19052 is a leukotriene antagonist developed by modifying leukotriene chemical structure. U-19052 can be used for the research of allergic asthma and hypersensitivity diseases.
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- CAS. Nr.: 112682-32-3
- Formel: C31H42O6S
- Molecular Weight:542.73
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Alle Leukotriene Receptor Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
Beschreibung
In Vitro
U-19052 (10 μM; 30 min) acts as a selective, competitive antagonist of peptidoleukotriene receptors on guinea pig tracheal strips, with a pKB of 6.43 against LTD4, 5.80 against LTE4, and 5.54 against LTC4[1].
U-19052 (10 μM; 10 min) inhibits LTE4-induced contraction of guinea pig tracheal strips without exhibiting agonist activity[1].
U-19052 (10 μM; 60 min) acts as a competitive antagonist of peptidoleukotriene receptors on guinea pig ileal segments, with a pKB of 7.25 against LTD4 and 7.17 against LTE4[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS. Nr. 112682-32-3
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Molecular Weight 542.73
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Formel C31H42O6S
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SMILES
CCCCCCCC(C=C1)=CC=C1C/C=C\[C@H]([C@@H](O)CCCC(O)=O)SCC2=C(C=C(C=C2)C(O)=O)OC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Ovalbumin-Induced Allergic Airway Inflammation
Ovalbumin-induced allergic airway inflammation is a mouse model in which systemic sensitization to ovalbumin, usually with aluminum hydroxide adjuvant, is followed by airway ovalbumin challenge to induce allergic airway inflammation, eosinophil recruitment, mucus production, serum antigen-specific IgE, Th2 cytokine responses, and airway hyperresponsiveness to methacholine. The model is used to study allergen-driven airway inflammation and asthma-like immune responses, but it does not reproduce every feature of human asthma. The main readouts are bronchoalveolar lavage fluid cellularity, lung histopathology, airway hyperresponsiveness, serum OVA-specific IgE, and cytokines such as IL-4, IL-5, and IL-13 in bronchoalveolar lavage fluid or lung samples. Eosinophilia and Th2 cytokines reflect allergic type 2 inflammation, while methacholine responsiveness provides a functional airway-reactivity endpoint.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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