XYDC2050
XYDC2050 (Compound 29) is a selective vasopressin V2 receptor (V2R) antagonist with an IC50 of 27 nM and a Ki of 2.8 nM. XYDC2050 shows a Ki of 420.7 nM (SI = 162 fold) for V1R. XYDC2050 can inhibit Vasopressin (HY-B1811)-induced intracellular cyclic adenosine monophosphate (cAMP) accumulation with an IC50 of 12 nM. XYDC2050 can inhibit the growth of renal cysts, reduce the ratio of kidney weight to body weight and decrease the area of cysts and the cystic index. XYDC2050 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C33H25FN2O4
- Molecular Weight:532.56
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Alle Vasopressin Receptor Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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V2 Receptor 27 nM (IC50) |
V2 Receptor 2.8 nM (Ki) |
Chemical Information
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Molecular Weight 532.56
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Formel C33H25FN2O4
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SMILES
FC1=CC=C(N(CC2=CC=C(O)C=C2)C(C3=CC(O)=C(NC(C4=CC=CC=C4C5=CC=CC=C5)=O)C=C3)=O)C=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
XYDC2050 Related Classifications
HY-180142 Related Classifications
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