Art. -Nr.: HY-B0836

λ-Cyhalothrin

4 Cited Publications

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Based on 4 publication(s) in Google Scholar

λ-Cyhalothrin is a high efficiency, broad-spectrum type II synthetic pyrethroid insecticide containing α-cyano group. λ-Cyhalothrin is used to control a wide range of pests in a variety of applications. λ-Cyhalothrin is a neurotoxin that targets sodium channels in the membranes of neurons in the central nervous system.

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Reinheit: 99.86%
CAS. Nr.: 91465-08-6
Formel: C₂₃H₁₉ClF₃NO₃
Molecular Weight:449.85

Speicherung:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

λ-Cyhalothrin Chemical Structure

CAS. Nr.: 91465-08-6

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (4)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Parasite Isoform-spezifische Produkte anzeigen :

Alle Sodium Channel Isoform-spezifische Produkte anzeigen :

In Vitro

The mechanism of λ-Cyhalothrin toxicity produces delay in sodium channel inactivation, which leads to persistent depolarization of the nerve membrane. λ-Cyhalothrin produces membrane depolarization, calcium ion infl ux, and neurotransmitter release from rat brain synaptosomes^[1].
λ-Cyhalothrin possesses estrogenic properties and has an ability to function as a xenoestrogen promoting human breast carcinoma cell proliferation in vitro^[1].
λ-Cyhalothrin has found multiple uses in pest (fleas, cockroaches, flies, and ants) control^[1].
λ-Cyhalothrin is highly effective against the malaria transmitting species of Anopheles^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The effect of λ-Cyhalothrin (i.p.) on memory, movement activity, and co-ordination in mice exposed to bilateral clamping of the carotid arteries (BCCA) is investigated. Neither memory nor movement co-ordination are impaired by BCCA or λ-Cyhalothrin. Exploratory locomotor activity is significantly reduced in the BCCA/LCH group. Spontaneous movement activity is significantly reduced in the BCCA/λ-Cyhalothrin group . Exposure to λ-Cyhalothrin coexisting with BCCA decreases motor activity in the mice in 2 subsequent 30-min^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 91465-08-6
Appearance Solid
Molecular Weight 449.85
Formel C₂₃H₁₉ClF₃NO₃
Color White to off-white
SMILES

O=C([C@@H]1C(C)(C)[C@@H]1/C=C(Cl)/C(F)(F)F)O[C@@H](C#N)C2=CC=CC(OC3=CC=CC=C3)=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (4)

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Environ Pollut

Effects of λ-cyhalothrin on the behavior and physiology of Leschenault's rousette bat (Rousettus leschenaultii). [Abstract]

2025 May 9:126417. PMID: 40349820
Environ Pollut

Foliar application of lambda-cyhalothrin modulates root exudate profile and the rhizosphere bacteria community of dioecious Populus cathayana. [Abstract]

2022 Nov 15:313:120123. PMID: 36087893
Chem Biol Interact

New insights into Lambda-cyhalothrin-induced lipid metabolism disorder in liver: Crosstalk between oxidative stress and PPARα signaling pathway. [Abstract]

2026 Jan 25:424:111872. PMID: 41386472
J Plant Ecol

24 August 2022.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 33.33 mg/mL (74.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2230 mL

11.1148 mL

22.2296 mL

5 mM

0.4446 mL

2.2230 mL

4.4459 mL

10 mM

0.2223 mL

1.1115 mL

2.2230 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (5.56 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

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Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (624 KB)
- English - EN (624 KB)
- Français - FR (624 KB)
- Deutsch - DE (624 KB)
- Norwegian - NO (624 KB)
- Español - ES (624 KB)
- Swedish - SV (624 KB)
- Italian - IT (624 KB)
- Korean - KR (624 KB)
- Portuguese - PT (624 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Barbara Nieradko-Iwanicka, et al. Effect of Lambda-Cyhalothrin on Memory and Movement in Mice After Transient Incomplete Cerebral Ischemia. Ann Agric Environ Med. 2011;18(1):41-5. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2230 mL	11.1148 mL	22.2296 mL	55.5741 mL
	5 mM	0.4446 mL	2.2230 mL	4.4459 mL	11.1148 mL
	10 mM	0.2223 mL	1.1115 mL	2.2230 mL	5.5574 mL
	15 mM	0.1482 mL	0.7410 mL	1.4820 mL	3.7049 mL
	20 mM	0.1111 mL	0.5557 mL	1.1115 mL	2.7787 mL
	25 mM	0.0889 mL	0.4446 mL	0.8892 mL	2.2230 mL
	30 mM	0.0741 mL	0.3705 mL	0.7410 mL	1.8525 mL
	40 mM	0.0556 mL	0.2779 mL	0.5557 mL	1.3894 mL
	50 mM	0.0445 mL	0.2223 mL	0.4446 mL	1.1115 mL
	60 mM	0.0370 mL	0.1852 mL	0.3705 mL	0.9262 mL

Keywords

λ-Cyhalothrin

4 Cited Publications

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λ-Cyhalothrin

Anti-Infection Compound Library

Membrane Transporter/Ion Channel Compound Library

Anti-Cancer Compound Library

Neuroprotective Compound Library

Antiparasitic Compound library

Sodium Channel Blocker Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Mitochondrial Toxicity Compound Library

Ion Channel Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Pesticide Compound Library

High-Throughput Bioactive Compound Library

Biotoxin Library

Environmental Pollutant Compound Library

Publications Citing Use of MedChemExpress (MCE) λ-Cyhalothrin

Alle Parasite Isoform-spezifische Produkte anzeigen

Alle Sodium Channel Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (4)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

λ-Cyhalothrin

Anti-Infection Compound Library

Membrane Transporter/Ion Channel Compound Library

Anti-Cancer Compound Library

Neuroprotective Compound Library

Antiparasitic Compound library

Sodium Channel Blocker Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Mitochondrial Toxicity Compound Library

Ion Channel Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Pesticide Compound Library

High-Throughput Bioactive Compound Library

Biotoxin Library

Environmental Pollutant Compound Library

Publications Citing Use of MedChemExpress (MCE) λ-Cyhalothrin

Alle Parasite Isoform-spezifische Produkte anzeigen

Alle Sodium Channel Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (4)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

λ-Cyhalothrin Related Classifications

HY-B0836 Related Classifications