CDP-840
CDP-840 (GR259653X) is a potent, selective and orally active phosphodiesterase IV (PDE IV) inhibitor. CDP-840 inhibits antigen-induced early and late phase bronchoconstriction in conscious squirrel monkeys.
For research use only. We do not sell to patients.
- CAS No.: 162542-90-7
- Formula: C25H27NO2
- Molecular Weight:373.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PDE4 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | IC50 |
10 μM
Compound: CDP-840
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Inhibition of recombinant human PDE4A expressed in Sf9 cells
Inhibition of recombinant human PDE4A expressed in Sf9 cells
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[PMID: 11052785] |
| Sf9 | IC50 |
4.2 nM
Compound: CDP-840
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Inhibition of human Phosphodiesterase 4A isoform using construct representing the common region of spliced variants expressed as GST-fusion proteins in Sf9 cells.
Inhibition of human Phosphodiesterase 4A isoform using construct representing the common region of spliced variants expressed as GST-fusion proteins in Sf9 cells.
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[PMID: 12270195] |
| Sf9 | IC50 |
4.3 nM
Compound: 3 (CDP-840)
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Inhibitory concentration against human PDE4A isoform using a construct representing the common region of spliced variants expressed as GST-fusion protein in Sf9 cells
Inhibitory concentration against human PDE4A isoform using a construct representing the common region of spliced variants expressed as GST-fusion protein in Sf9 cells
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[PMID: 12031319] |
| U-937 | EC50 |
0.29 μM
Compound: CDP 840
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Arbitary maximal response for cAMP elevation from baseline level was evaluated in Human U-937 cells
Arbitary maximal response for cAMP elevation from baseline level was evaluated in Human U-937 cells
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[PMID: 9632360] |
Chemical Information
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CAS No. 162542-90-7
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Molecular Weight 373.49
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Formula C25H27NO2
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SMILES
COC1=CC=C([C@@H](C2=CC=CC=C2)CC3=CC=NC=C3)C=C1OC4CCCC4
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Synonyms
GR259653X
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDP-840 Related Classifications
HY-108620 Related Classifications
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