APOC4 - apolipoprotein C4 Gene

Also Known as APO-CIV; APOC-IV

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 346

About APOC4

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:44,942,237-44,945,496 (from NCBI)

This gene has 2 transcripts (splice variants) and 77 orthologues. Restricted expression toward liver (RPKM 124.3).

Summary

This gene encodes a lipid-binding protein belonging to the Apolipoprotein gene family. The protein is thought to play a role in lipid metabolism. Polymorphisms in this gene may influence circulating lipid levels and may be associated with coronary artery disease risk. This gene is present in a cluster with Other related Apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring downstream Apolipoprotein C-II (APOC2) gene. [provided by RefSeq, Mar 2011]

APOC4 Products (1)

mRNA Protein Name
NM_001646.3 NP_001637.1 apolipoprotein C-IV precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of sequestering of triglyceride IMP
IMP: Inferred from mutant phenotype
18809223 GOA
involved in triglyceride homeostasis IMP
IMP: Inferred from mutant phenotype
8827523 GOA
Cellular Component GO Annotation Evidence References Source
part of high-density lipoprotein particle IDA
IDA: Inferred from direct assay
12700345 GOA
part of very-low-density lipoprotein particle IDA
IDA: Inferred from direct assay
12700345 GOA
part of very-low-density lipoprotein particle IMP
IMP: Inferred from mutant phenotype
8827523 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOC4 Protein Structure

APOC4

APOC4: Apolipoprotein C4 (27 - 125)

  • 0
  • 100
  • 127 a.a.
Protein Preferred Names Protein Names

apolipoprotein C-IV

APOC4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
APOC4 P55056 SYT16 Homo sapiens Q17RD7
Validated Y2H
32296183
Intra
APOC4 P55056 SNAP47 Homo sapiens Q5SQN1
Validated Y2H
32296183
Intra
APOC4 P55056 MAIP1 Homo sapiens Q8WWC4
Validated Y2H
32296183
Intra
APOC4 P55056 MICOS13 Homo sapiens Q5XKP0
Validated Y2H
32296183
Intra
APOC4 P55056 GSDMA Homo sapiens Q96QA5
Validated Y2H
32296183
Intra
APOC4 P55056 RSAD2 Homo sapiens Q8WXG1
Validated Y2H
32296183
Intra
APOC4 P55056 MICOS10 Homo sapiens Q5TGZ0
Validated Y2H
32296183
Intra
APOC4 P55056 LETMD1 Homo sapiens Q6P1Q0
Validated Y2H
32296183
Intra
APOC4 P55056 TPRG1 Homo sapiens Q6ZUI0
Validated Y2H
32296183
Intra
APOC4 P55056 PORCN Homo sapiens Q9H237-2
Validated Y2H
32296183
Intra
APOC4 P55056 APOL2 Homo sapiens Q9BQE5
Validated Y2H
32296183
Intra
APOC4 P55056 DIABLO Homo sapiens Q9NR28
Validated Y2H
32296183
Intra
APOC4 P55056 TIMMDC1 Homo sapiens Q9NPL8
Validated Y2H
32296183
Intra
APOC4 P55056 BCL2L2 Homo sapiens Q92843
Validated Y2H
32296183
Intra
APOC4 P55056 SENP2 Homo sapiens Q9HC62
Validated Y2H
32296183
Intra
APOC4 P55056 NFU1 Homo sapiens Q9UMS0
Validated Y2H
32296183
Intra
APOC4 P55056 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
APOC4 P55056 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
APOC4 P55056 TBC1D20 Homo sapiens Q96BZ9
Validated Y2H
32296183
Intra
APOC4 P55056 TBC1D20 Homo sapiens Q96BZ9
Y2H Array
32296183
Intra
APOC4 P55056 GAD2 Homo sapiens Q05329
Validated Y2H
32296183
Intra
APOC4 P55056 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hyperlipoproteinemia, Type Iv

  • Hyperlipoproteinemia Type Iv

  • Carbohydrate-Inducible Hyperlipemia

  • Endogenous Hyperlipidaemia

  • Familial Hypertriglyceridemia

  • Fredrickson Type Iv Hyperlipoproteinemia

  • Fredrickson Type Iv Lipidaemia

  • Fredrickson Type Iv Lipidemia

  • Vldl Hyperlipoproteinemia

  • Hyperlipoproteinemia Type 4

  • Carbohydrate Inducible Hyperlipemia

  • Familial Type Iv Hyperlipoproteinemia

  • Familial Hyperlipoproteinemia Type Iv
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00847 APOC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus APOC4 MGD MGI:87878
Felis catus APOC4 VGNC VGNC:103060
Canis familiaris APOC4 VGNC VGNC:53523
Bos taurus APOC4 VGNC VGNC:52177
Macaca mulatta APOC4 VGNC VGNC:109594
Rattus norvegicus APOC4 RGD RGD:70959
Others APOC4 NCBI