CEACAM6 - CEA cell adhesion molecule 6 Gene

Also Known as NCA; CEAL; CD66c

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4680

About CEACAM6

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:41,755,530-41,772,211 (from NCBI)

This gene has 2 transcripts (splice variants), 568 orthologues, 24 paralogues and is associated with 1 phenotype. Biased expression in colon (RPKM 147.4), lung (RPKM 142.2) and 9 other tissues.

Summary

This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum Immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus Infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]

CEACAM6 Products (1)

mRNA	Protein	Name
NM_002483.7	NP_002474.4	carcinoembryonic antigen-related cell adhesion molecule 6 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	26483485	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	21982860	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21982860	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	26483485	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IMP IMP: Inferred from mutant phenotype	2803308	GOA
involved in homophilic cell adhesion via plasma membrane adhesion molecules	IMP IMP: Inferred from mutant phenotype	2803308	GOA
involved in negative regulation of anoikis	IMP IMP: Inferred from mutant phenotype	10910050	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	16204051	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	25171863	GOA
involved in positive regulation of endothelial cell-matrix adhesion via fibronectin	IMP IMP: Inferred from mutant phenotype	16204051	GOA
involved in positive regulation of heterotypic cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	16204051	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	10436421	GOA
located in cell surface	IDA IDA: Inferred from direct assay	2317824	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	25645918	GOA
located in membrane	IDA IDA: Inferred from direct assay	2317824	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CEACAM6 Protein Structure

V-set

Ig_3

Ig_2

0
100
200
300
344 a.a.

Protein Preferred Names	Protein Names
carcinoembryonic antigen-related cell adhesion molecule 6	Cluster of Differentiation 66c

CEACAM6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CEACAM6	P40199	MSS51	Homo sapiens	Q4VC12	Validated Y2H	32296183
Intra	CEACAM6	P40199	MSS51	Homo sapiens	Q4VC12	Y2H Array	32296183
Intra	CEACAM6	P40199	MSS51	Homo sapiens	Q4VC12	Y2H Prey Pooling	32296183
Intra	CEACAM6	P40199	POM121	Homo sapiens	Q96HA1-2	Validated Y2H	32296183
Intra	CEACAM6	P40199	VEZF1	Homo sapiens	Q14119	Validated Y2H	32296183
Intra	CEACAM6	P40199	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
Intra	CEACAM6	P40199	ASPG	Homo sapiens	Q86U10	Validated Y2H	32296183
Intra	CEACAM6	P40199	ASPG	Homo sapiens	Q86U10	Y2H Array	32296183
Intra	CEACAM6	P40199	ASPG	Homo sapiens	Q86U10	Y2H Prey Pooling	32296183
Intra	CEACAM6	P40199	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	32296183
Intra	CEACAM6	P40199	QRICH1	Homo sapiens	Q2TAL8	Validated Y2H	32296183
Intra	CEACAM6	P40199	EXOC3L1	Homo sapiens	Q86VI1	Validated Y2H	32296183
Intra	CEACAM6	P40199	SMARCD1	Homo sapiens	Q96GM5	Validated Y2H	32296183
Intra	CEACAM6	P40199	RHOXF2	Homo sapiens	Q9BQY4	Validated Y2H	32296183
Intra	CEACAM6	P40199	CIB1	Homo sapiens	Q99828	Y2H Prey Pooling	32296183
Intra	CEACAM6	P40199	CIB1	Homo sapiens	Q99828	Validated Y2H	32296183
Intra	CEACAM6	P40199	CIB1	Homo sapiens	Q99828	Y2H Array	32296183
Intra	CEACAM6	P40199	CEACAM6	Homo sapiens	P40199	Y2H Prey Pooling	32296183
Intra	CEACAM6	P40199	CEACAM6	Homo sapiens	P40199	Protein Array	21982860
Intra	CEACAM6	P40199	CEACAM6	Homo sapiens	P40199	Validated Y2H	32296183
Intra	CEACAM6	P40199	HPCAL4	Homo sapiens	Q9UM19	Validated Y2H	32296183
Intra	CEACAM6	P40199	CEACAM6	Homo sapiens	P40199	Y2H Array	32296183
Intra	CEACAM6	P40199	CEACAM6	Homo sapiens	P40199	Solution Sedimentation	26483485
Intra	CEACAM6	P40199	CEACAM8	Homo sapiens	P31997	X-Ray Diffraction	26483485
Intra	CEACAM6	P40199	HPCAL4	Homo sapiens	Q9UM19	Y2H Array	32296183
Intra	CEACAM6	P40199	CEACAM6	Homo sapiens	P40199	X-Ray Diffraction	26483485
Intra	CEACAM6	P40199	HPCAL4	Homo sapiens	Q9UM19	Y2H Prey Pooling	32296183
Intra	CEACAM6	P40199	CARTPT	Homo sapiens	Q16568	Protein Array	21982860
Intra	CEACAM6	P40199	CARTPT	Homo sapiens	Q16568	SPR	21982860
Intra	CEACAM6	P40199	MYOZ1	Homo sapiens	Q9NP98	Validated Y2H	32296183
Intra	CEACAM6	P40199	ZMYND19	Homo sapiens	Q96E35	Validated Y2H	32296183
Intra	CEACAM6	P40199	ZMYND19	Homo sapiens	Q96E35	Y2H Prey Pooling	32296183
Intra	CEACAM6	P40199	ZMYND19	Homo sapiens	Q96E35	Y2H Array	32296183
Intra	CEACAM6	P40199	PITX1	Homo sapiens	P78337	Validated Y2H	32296183
Intra	CEACAM6	P40199	SHC3	Homo sapiens	Q92529	Validated Y2H	32296183
Intra	CEACAM6	P40199	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	CEACAM6	P40199	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	CEACAM6	P40199	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CEACAM6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72131	CEACAM6 Protein, Human (His-SUMO)	P40199 (K35-G320, V239G)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P75671	CEACAM6 Protein, Human (Biotinylated, HEK293, His)	P40199 (K35-G320)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78081	CEACAM6 Protein, Human (Biotinylated, HEK293, His-Avi)	P40199 (K35-G320)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78397	CEACAM6 Protein, Human (HEK293, His-Avi)	P40199 (K35-G320)	≥ 95%, as determined by Bis-Tris PAGE.

CEACAM6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83606	CEACAM6 Antibody (YA3351)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P84295	CEACAM6 Antibody (YA3992)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
HY-P84295A	CEACAM6 Antibody (YA3992)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Granulomatous Colitis Enteritis, Granulomatous Enteritis Crohn'S Disease Of Colon Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Gastrointestinal Carcinoma	Gastrointestinal Neoplasms
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Pancreatic Adenocarcinoma	Adenocarcinoma Of The Pancreas Adenocarcinoma Of Pancreas Pancreas Adenocarcinoma Malignant Exocrine Neoplasm Primary Pancreatic Adenocarcinoma Adenocarcinoma Of Islet Cell Of Pancreas Islet Cell Adenocarcinoma Of Unspecified Site Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Cholangiocarcinoma	Cholangiocarcinoma, Susceptibility To Extrahepatic Cholangiocarcinoma Intrahepatic Cholangiocarcinoma Chlc Chlc, Susceptibility To Cc Cholangiocarcinoma Of Biliary Tract Cholangiocellular Carcinoma Distal Cholangiocarcinoma Perihilar Cholangiocarcinoma Bile Duct Cancer Cca Adult Primary Cholangiocellular Carcinoma Bile Duct Carcinoma
Ovarian Mucinous Adenocarcinoma	Mucinous Carcinoma Of Ovary
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99051	Tinurilimab	Inhibitor	98.01%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-164899	2A3		99.92%	Unkown
HY-RS02442	CEACAM6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24916	Ceacam6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99691	Lemalesomab	Inhibitor	/	Unkown
HY-P992344	DNP002	Inhibitor	/	Unkown
HY-P992350	EBC-129 Antibody		/	Unkown
HY-P990854	Anti-CEACAM1/3/5/6/8 Antibody (6G5j)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CEACAM6	RGD	RGD:1642421
Others	CEACAM6	NCBI