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Cat. No.: HY-P992458

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SBT8230 Antibody

SBT8230 Antibody is the antibody moiety of SBT8230, and belongs to anti-ASGR1 antibodies. SBT8230 is an ASGR1-targeted TLR8 agonist, which acts as an ASGR1-TLR8 immune-targeting antibody conjugate (ISAC). SBT8230 activates myeloid cells and induces anti-HBV immune responses. SBT8230 is applicable to research on chronic hepatitis B infection. The isotype control for SBT8230 Antibody is Human IgG1 kappa, Isotype Control (HY-P99001).

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SBT8230 Antibody Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

TLR8

In Vitro

SBT8230 Antibody is the antibody component of SBT8230. As a liver-targeted TLR8 agonist against ASGR1, SBT8230 activates myeloid cells in hepatocyte models and induces anti-HBV immune responses and antiviral T-cell responses^[1]^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SBT8230 Antibody is the antibody component of SBT8230. SBT8230 induces anti-HBs seroconversion and antiviral T-cell responses in HBV mouse models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gene ID

432 [NCBI]

Accession

P07306

Target

ASGR1

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

Application

ELISA, FACS, Functional assay

Chemical Information

Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Gan L, et al. A High-Throughput Cell-Based Luciferase Reporter Assay for Identifying Inhibitors of ASGR1. Int J Mol Sci. 2025;26(10):4590. Published 2025 May 10. [Content Brief]

[2]. Mak LY, et al. New strategies for the treatment of chronic hepatitis B. Trends Mol Med. 2022;28(9):742-757. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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