4L2-P13D
4L2-P13D is an IL-11 antagonist with an IC50 of 2.8 μM. 4L2-P13D has a KD of 11 nM for hIL-11. 4L2-P13D exhibits antifibrotic and renoprotective activities. 4L2-P13D can be used in the research of renal fibrosis.
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- Formule: C89H123N19O23S
- Masse moléculaire:1859.11
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Stockage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
4L2-P13D (0.5-5 μM; 72 h) reduces the expression of profibrotic factors (FN1, COL1A1) in TGF-β1-induced HK-2 cells in a dose-dependent manner[1].
4L2-P13D (0-50 μM; 24 h) exhibits no cytotoxicity against HK-2 cells even at concentrations as high as 50 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:TGF-β1-induced human proximal tubular epithelial (HK-2) cells
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Concentration:0.5, 2 and 5 μM
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Incubation Time:72 h
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Result:Dose-dependently reduced fibronectin (FN1) and type I collagen (COL1A1) expression.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (male, 6-8 weeks old, UUO model)[1]
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Dosage:0.5 mg/kg; 2 mg/kg
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Administration:s.c.; daily; 7 days
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Result:Significantly reduced expression levels of fibrosis markers FN1 and α-smooth muscle α-SMA.
Remarkably reduced proinflammatory markers (TNF-α, TGF-β1, IL-6, IL-1β) and kidney injury markers (Kim1, Ngal).
Reduced blood urea nitrogen (BUN) and creatinine levels.
Significantly improved collagen deposition, with the high-dose group showing superior efficacy compared to the low-dose group.
Chemical Information
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Appearance Solid
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Masse moléculaire 1859.11
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Formule C89H123N19O23S
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Color White to off-white
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Sequence
Ac-Tyr-Leu-Ile-Gln-His-Tyr-Tyr-Thr-Phe-Ile-Ala-Leu-Asp-Cys-Gly-NH2 (sulfide bridge: Tyr1-Cys14)
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Sequence Shortening
Ac-YLIQHYYTFIALDCG-NH2 (sulfide bridge: Tyr1-Cys14)
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Pureté et documentation
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Fiche technique (263 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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