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Cyclopamine

(Synonyms: 11-Deoxojervine)
56 Cited Publications
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Based on 56 publication(s) in Google Scholar

Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC50 of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.

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  • Pureté: 99.68%
  • CAS No.: 4449-51-8
  • Formule: C27H41NO2
  • Masse moléculaire:411.62
  • Stockage:

    4°C, sealed storage, away from moisture and light

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

  • Cyclopamine Chemical Structure
    Cyclopamine Chemical Structure
  • Experimental Validation Results for Cyclopamine
  • Experimental Validation Results for Cyclopamine
  • Experimental Validation Results for Cyclopamine
  • Experimental Validation Results for Cyclopamine
  • Experimental Validation Results for Cyclopamine
  • Experimental Validation Results for Cyclopamine
CAS No.: 4449-51-8
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  • Cyclopamine Chemical Structure
    Cyclopamine Chemical Structure
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    Cyclopamine purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2019 Sep 12;10(9):681. [Abstract]

    Customer Validation
     Endometrial stromal cells are stimulated with 10 ng/mL TGFβ1 for 48 h. Then these cells are treated with 10 μM Cyc for 24 h and/or cocultured with 10 ng/mL VEGF165 for another 12 or 24 h. The protein levels of collagen 1, α-SMA and smad7 are examined.

  • 1/16

    Cyclopamine purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2019 Sep 12;10(9):681. [Abstract]

    Customer Validation
     Endometrial stromal cells are stimulated with 10 ng/mL TGFβ1 for 48 h. Then these cells are treated with 10 μM Cyc for 24 h and/or cocultured with 10 ng/mL VEGF165 for another 12 or 24 h. The protein levels of collagen 1, α-SMA and smad7 are examined.

  • 1/16

    Cyclopamine purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Jun 26:9:674. [Abstract]

    Customer Validation
     Cyclopamine and GANT61 decrease the level of Gli1 as evidenced by western blot.

  • 1/16

    Cyclopamine purchased from MedChemExpress. Usage Cited in: Int J Nanomedicine. 2017 Apr 20:12:3267-3280. [Abstract]

    Customer Validation
     The Smo inhibitor Cyclopamine suppresses the activity of Hedgehog–Gli1 signaling. The gene expression and protein production of Smo in MG63 osteoblasts after 7 days of incubation on the different titanium surfaces.

  • 1/16

    Cyclopamine purchased from MedChemExpress. Usage Cited in: Life Sci. 2017 Dec 15:191:82-89. [Abstract]

    Customer Validation
     ORS cells are exposed to 3% oxygen for 48 h in presence or absence of Shh pathway inhibitor cyclopamine (5 μM) or GANT61 (10 μM). Immunofluorescence assay using anti-PCNA antibody is performed to detect the proliferative ORS cells (red). Cell nuclei are counterstained with DAPI (blue).

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    Cyclopamine purchased from MedChemExpress. Usage Cited in: Neurochem Res. 2016 Apr;41(4):687-95. [Abstract]

    Customer Validation
     Western blot and RT-qPCR assays of BDNF protein and gene expressions in primary cortical neurons in different experimental conditions. Immunoblotting bands of BDNF protein.

  • Cyclopamine