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GSK2606414

134 Cited Publications
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Based on 134 publication(s) in Google Scholar

GSK2606414 is a cell-permeable and orally available protein kinase R-like endoplasmic reticulum (ER) kinase (PERK) inhibitor with an IC50 of 0.4 nM.

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  • Pureté: 99.91%
  • CAS No.: 1337531-36-8
  • Formule: C24H20F3N5O
  • Masse moléculaire:451.44
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    4°C, protect from light

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

  • GSK2606414 Chemical Structure
    GSK2606414 Chemical Structure
  • Experimental Validation Results for GSK2606414
  • Experimental Validation Results for GSK2606414
  • Experimental Validation Results for GSK2606414
  • Experimental Validation Results for GSK2606414
  • Experimental Validation Results for GSK2606414
  • Experimental Validation Results for GSK2606414
  • Experimental Validation Results for GSK2606414
CAS No.: 1337531-36-8
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  • GSK2606414 Chemical Structure
    GSK2606414 Chemical Structure
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    GSK2606414 purchased from MedChemExpress. Usage Cited in: NPJ Parkinsons Dis. 2023 Mar 7;9(1):35. [Abstract]

    Customer Validation
     Co-application of 100 nM GSK2606414 or 100 nM KIRA8 with 10 nM thapsigargin for 48 h significantly mitigate thapsigargin-induced cell death of both the Ctrl and iKO (inducible knockout) midbrain DAergic neurons of mice.

  • 1/16

    GSK2606414 purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2022 Dec 21;10(6):e0328222. [Abstract]

    Customer Validation
     GSK2606414 (10 µM; 24 h) or C16 (1 µM; 24 h) substantially decreases MGF110-7L-induced phosphorylation of PERK, PKR, and eIF2a in 3D4/21 cells (transfected with an empty Flag vector or a MGF110-7LFlag-expressing vector).

  • 1/16

    GSK2606414 purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01442-18. [Abstract]

    Customer Validation
     Extracellular tachyzoites are treated with 1 µM Thapsigargin in the presence of different concentrations of GSK2606414 (PERKi) as indicated or incubated with vehicle (DMSO) for 1 hour.

  • 1/16

    GSK2606414 purchased from MedChemExpress. Usage Cited in: Neuroscience. 2018 Apr 1:375:34-48. [Abstract]

    Customer Validation
     Western blot analysis of p-eIF2α in axotomized DRG spot cultures pretreated with or without GSK2606414 (10 μM) 30 min prior to axotomy. Cells are collected 1 h after axotomy.

  • 1/16

    GSK2606414 purchased from MedChemExpress. Usage Cited in: PLoS One. 2018 Apr 9;13(4):e0194310. [Abstract]

    Customer Validation
     HeLa cells are treated with Tun in the absence or presence of PERK kinase inhibitor GSK2606414 (1 μM) with DMSO as the control. Total cell lysates are prepared, normalized for total protein and immunoblotting of indicated proteins ASB7, CHOP and ATF4 for 6 h in HeLa cells.

  • 1/16

    GSK2606414 purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2017 Dec 13;22(6):766-776.e4. [Abstract]

    Customer Validation
     Effects of GSK2606414 on the levels of Plasmodium eIF2a phosphorylation 24 hr after 75 mg/kg GSK2606414 treatment of mice infected with asynchronized P. berghei ANKA (A) and 48 hr after 2 mM GSK2606414 treatment of asynchronized P. falciparum 3D7 parasites in culture (B).

  • 1/16

    GSK2606414 purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2016 Nov 11;480(2):166-172. [Abstract]

    Customer Validation
     An inhibitor of PERK, GSK2606414, is examined. Treatment and immunostaining are performed as per. Note that large CD63 and Rab7 positive vesicles appeared during ER stress when cells are pre-treated with GSK2606414.

  • GSK2606414