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Cat. No.: HY-18604

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K-Ras G12C-IN-1

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C extracted from patent WO 2014152588 A1.

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Pureté: 98.19%
CAS No.: 1629265-17-3
Formule: C₂₂H₂₃Cl₂N₃O₃
Masse moléculaire:448.34

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

K-Ras G12C-IN-1 Chemical Structure

CAS No.: 1629265-17-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C extracted from patent WO 2014152588 A1. IC50 value: Target: K-ras G12C inhibitor

Voir tous les produits spécifiques à Isoform Ras :

Chemical Information

CAS No. 1629265-17-3
Appearance Solid
Masse moléculaire 448.34
Formule C₂₂H₂₃Cl₂N₃O₃
Color White to off-white
SMILES

ClC(C=C(OC)C(NCC(N1CCN(C(C=C)=O)CC1)=O)=C2)=C2C3=CC=CC=C3Cl
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (1)

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Cell Chem Biol

Systematic cysteine scanning identifies a druggable pocket in oncogenic KRAS. [Abstract]

2026 Feb 11:S2451-9456(26)00027-9. PMID: 41679298

Solvant et solubilité

In Vitro:

DMSO : ≥ 40 mg/mL (89.22 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2305 mL

11.1523 mL

22.3045 mL

5 mM

0.4461 mL

2.2305 mL

4.4609 mL

10 mM

0.2230 mL

1.1152 mL

2.2305 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (242 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2305 mL	11.1523 mL	22.3045 mL	55.7613 mL
	5 mM	0.4461 mL	2.2305 mL	4.4609 mL	11.1523 mL
	10 mM	0.2230 mL	1.1152 mL	2.2305 mL	5.5761 mL
	15 mM	0.1487 mL	0.7435 mL	1.4870 mL	3.7174 mL
	20 mM	0.1115 mL	0.5576 mL	1.1152 mL	2.7881 mL
	25 mM	0.0892 mL	0.4461 mL	0.8922 mL	2.2305 mL
	30 mM	0.0743 mL	0.3717 mL	0.7435 mL	1.8587 mL
	40 mM	0.0558 mL	0.2788 mL	0.5576 mL	1.3940 mL
	50 mM	0.0446 mL	0.2230 mL	0.4461 mL	1.1152 mL
	60 mM	0.0372 mL	0.1859 mL	0.3717 mL	0.9294 mL
	80 mM	0.0279 mL	0.1394 mL	0.2788 mL	0.6970 mL

Keywords

K-Ras G12C-IN-1

1 Cited Publications

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Chemical Information
Publications (1)
Solvant et solubilité
- In Vitro
Pureté et documentation

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K-Ras G12C-IN-1

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

MAPK Compound Library

Anti-Cancer Compound Library

Covalent Screening Library

Oxygen Sensing Compound Library

Ferroptosis Compound Library

Glutamine Metabolism Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Angiogenesis-Related Compound Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cysteine Targeted Covalent Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) K-Ras G12C-IN-1

Voir tous les produits spécifiques à Isoform Ras

Activité biologique

Chemical Information

Publications (1)

Solvant et solubilité

Pureté et documentation

Help & FAQs

Complete Stock Solution Preparation Table

K-Ras G12C-IN-1

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

MAPK Compound Library

Anti-Cancer Compound Library

Covalent Screening Library

Oxygen Sensing Compound Library

Ferroptosis Compound Library

Glutamine Metabolism Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Angiogenesis-Related Compound Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cysteine Targeted Covalent Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) K-Ras G12C-IN-1

Voir tous les produits spécifiques à Isoform Ras

Activité biologique

Chemical Information

Publications (1)

Solvant et solubilité

Pureté et documentation

Help & FAQs

Complete Stock Solution Preparation Table

K-Ras G12C-IN-1 Related Classifications

HY-18604 Related Classifications