Cat. No.: HY-14621

Zingerone

(Synonyms: Vanillylacetone; Gingerone)

6 Cited Publications

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Based on 6 publication(s) in Google Scholar

Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor properties. Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways. Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells. Zingerone can cross the blood-brain barrier (BBB).

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Pureté: 99.77%
CAS No.: 122-48-5
Formule: C₁₁H₁₄O₃
Masse moléculaire:194.23

Stockage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Zingerone Chemical Structure

CAS No.: 122-48-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Essai clinique
Chemical Information
Publications (6)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor^[3] properties^[1]. Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways^[2]. Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells^[3]. Zingerone can cross the blood-brain barrier (BBB)^[4].

IC₅₀ & Target

NF-κB^[3]

Voir tous les produits spécifiques à Isoform NF-κB :

Cellular Effect

Cell Line	Type	Value	Description	References
B16	IC₅₀	>100 μM Compound: 9	Inhibition of melanogenesis in theophylline-stimulated mouse B16-4A5 cells after 72 hrs Inhibition of melanogenesis in theophylline-stimulated mouse B16-4A5 cells after 72 hrs	[PMID: 19615910]
B16-4A5	IC₅₀	>100 μM Compound: 9	Inhibition of theophylline-stimulated mouse B16-4A5 cell proliferation assessed as cell viability after 68 hrs by WST8 assay Inhibition of theophylline-stimulated mouse B16-4A5 cell proliferation assessed as cell viability after 68 hrs by WST8 assay	[PMID: 19615910]
IMR-32	ED₅₀	>129 μM Compound: 3	Effective dose to protect IMR-32 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay Effective dose to protect IMR-32 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay	[PMID: 14980683]
PC-12	ED₅₀	>129 μM Compound: 3	Effective dose to protect PC12 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay Effective dose to protect PC12 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay	[PMID: 14980683]

In Vitro

Zingerone is a nontoxic methoxyphenol with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic properties^[1].
Zingerone (0-2 mM) decreases neruoblastoma cell survival^[3].
Zingerone (0-2 mM) reduces cyclin D1 expression, increases cleavage of caspase-3 and PARP-1 in BE(2)-M17 cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Zingerone (50, 100 mg/kg, p.o. daily for 21 days) protects against alloxan-induced diabetes via alleviation of oxidative stress and inflammation in rat^[2].
Zingerone (10 mg/kg, i.p.) inhibits tumor progression through mitotic arrest, failure of cell division, and stimulation of apoptosis^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 122-48-5
Appearance Solid
Masse moléculaire 194.23
Formule C₁₁H₁₄O₃
Color White to off-white
SMILES

COC1=C(O)C=CC(CCC(C)=O)=C1
Synonyms

Vanillylacetone; Gingerone
Structure Classification
- Phenols
- Monophenols
- Ketones, Aldehydes, Acids
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (6)

All Cell Proliferation/Viability AssayHistological Imaging/StainingWBCell Imaging/StainingIn Vivo Efficacy Study

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Journal Impact Factor

Int J Mol Sci

Characterization in Effective Stimulation on the Magnitude, Gating, Frequency Dependence, and Hysteresis of INa Exerted by Picaridin (or Icaridin), a Known Insect Repellent. [Abstract]

2022 Aug 26;23(17):9696. PMID: 36077093
Int Immunopharmacol

Zingerone attenuates concanavalin A-induced acute liver injury by restricting inflammatory responses. [Abstract]

2024 Sep 20;142(Pt B):113198. PMID: 39305891
Microorganisms

The Effect of Variations in Temperature and Contact Time of Zingerone, [6]-Gingerol and Shogaol as Disinfectants on Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans. [Abstract]

2026 Feb 26;14(3):539. PMID: 41900299
J Funct Foods

2024 Aug.
Curr Issues Mol Biol

Zingerone Targets LKB1/AMPK to Block FcεRI-Dependent Mast Cell Degranulation and Anaphylaxis. [Abstract]

2025 Nov 19;47(11):963. PMID: 41296467

Zingerone purchased from MedChemExpress. Usage Cited in: Curr Issues Mol Biol. 2025 Nov 19;47(11):963. [Abstract]

Zingerone demonstrated no cytotoxicity toward BMMCs and RBL-2H3 cells after 8 h of incubation across concentrations of 1–50 μM, as quantified by CCK-8 assays.

Zingerone purchased from MedChemExpress. Usage Cited in: Curr Issues Mol Biol. 2025 Nov 19;47(11):963. [Abstract]

IgE-sensitized BMMCs were pretreated with graded Zingerone concentrations (10, 20 μM, 2 h) followed by DNP-HSA (Ag) stimulation (15 min–8 h). Immunoblotting of cell lysates demonstrated dose-dependent inhibition of FcεRI-proximal signaling phosphoproteins.

Zingerone purchased from MedChemExpress. Usage Cited in: Curr Issues Mol Biol. 2025 Nov 19;47(11):963. [Abstract]

Zingerone (10, 20 μM) improves AMPK enucleation by mast cell activation by immunofluorescence staining.

Zingerone purchased from MedChemExpress. Usage Cited in: Curr Issues Mol Biol. 2025 Nov 19;47(11):963. [Abstract]

Ear tissue dye extravasation was quantified after 1 h by formamide extraction at 63 °C overnight and quantified by absorbance at 630 nm treated with Zingerone (25 or 50 mg/kg, p.o.).
Saudi J Biol Sci

Zingerone attenuates intestinal injury and colitis caused by a high-fat diet through Nrf2 signaling regulation. [Abstract]

2023 Oct;30(10):103775. PMID: 37766888

Zingerone purchased from MedChemExpress. Usage Cited in: Saudi J Biol Sci. 2023 Oct;30(10):103775. [Abstract]

Photomicrographs were taken from control and Zingerone (100 mg/kg, p.o.)-treated animals and demonstrated normal duodenal histology of the epithelia with obvious intact microvilli (long arrow) at the top of the mucosa, goblet cells (short arrow), and intestinal crypts (arrowhead).

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (514.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.1485 mL

25.7427 mL

51.4854 mL

5 mM

1.0297 mL

5.1485 mL

10.2971 mL

10 mM

0.5149 mL

2.5743 mL

5.1485 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (12.87 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (12.87 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (12.87 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ahmad B, et al. A Review on Pharmacological Properties of Zingerone (4-(4-Hydroxy-3-methoxyphenyl)-2-butanone). ScientificWorldJournal. 2015;2015:816364. [Content Brief]

[2]. Ahmad B, et al. Zingerone (4-(4-hydroxy-3-methylphenyl) butan-2-one) protects against alloxan-induced diabetes via alleviation of oxidative stress and inflammation: Probable role of NF-kB activation. Saudi Pharm J. 2018 Dec;26(8):1137-1145. [Content Brief]

[3]. Choi JS, et al. Zingerone Suppresses Tumor Development through Decreasing Cyclin D1 Expression and Inducing Mitotic Arrest. Int J Mol Sci. 2018 Sep 19;19(9). [Content Brief]

[4]. Rashid S, et al. Zingerone Targets Status Epilepticus by Blocking Hippocampal Neurodegeneration via Regulation of Redox Imbalance, Inflammation and Apoptosis. Pharmaceuticals (Basel). 2021 Feb 11;14(2):146. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	5.1485 mL	25.7427 mL	51.4854 mL	128.7134 mL
	5 mM	1.0297 mL	5.1485 mL	10.2971 mL	25.7427 mL
	10 mM	0.5149 mL	2.5743 mL	5.1485 mL	12.8713 mL
	15 mM	0.3432 mL	1.7162 mL	3.4324 mL	8.5809 mL
	20 mM	0.2574 mL	1.2871 mL	2.5743 mL	6.4357 mL
	25 mM	0.2059 mL	1.0297 mL	2.0594 mL	5.1485 mL
	30 mM	0.1716 mL	0.8581 mL	1.7162 mL	4.2904 mL
	40 mM	0.1287 mL	0.6436 mL	1.2871 mL	3.2178 mL
	50 mM	0.1030 mL	0.5149 mL	1.0297 mL	2.5743 mL
	60 mM	0.0858 mL	0.4290 mL	0.8581 mL	2.1452 mL
	80 mM	0.0644 mL	0.3218 mL	0.6436 mL	1.6089 mL
	100 mM	0.0515 mL	0.2574 mL	0.5149 mL	1.2871 mL

Keywords

Zingerone

6 Cited Publications

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Zingerone

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Publications Citing Use of MedChemExpress (MCE) Zingerone

Voir tous les produits spécifiques à Isoform NF-κB

Activité biologique

Chemical Information

Publications (6)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Zingerone Related Classifications

HY-14621 Related Classifications