Ainsliadimer A
Ainsliadimer A is a sesquiterpene lactone dimer with an unusual carbon skeleton. Ainsliadimer A can be obtained from from Ainsliaea macrocephala. Ainsliadimer A inhibits the production of nitric oxide in cells stimulated by LPS.
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- CAS No.: 1039431-94-1
- Formule: C30H34O7
- Masse moléculaire:506.59
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| C6 | IC50 |
4.3 μM
Compound: 8
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Cytotoxicity against rat C6 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
Cytotoxicity against rat C6 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
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[PMID: 34496568] |
| HCCLM3 | IC50 |
>10 μM
Compound: 8
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Cytotoxicity against human HCCLM3 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
Cytotoxicity against human HCCLM3 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
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[PMID: 34496568] |
| HeLa | IC50 |
5.3 μM
Compound: 8
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Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
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[PMID: 34496568] |
| Huh-7 | IC50 |
4.4 μM
Compound: 8
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Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
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[PMID: 34496568] |
| PANC-1 | IC50 |
9.9 μM
Compound: 8
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Cytotoxicity against human PANC-1 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
Cytotoxicity against human PANC-1 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
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[PMID: 34496568] |
| RAW264.7 | IC50 |
2.41 μg/mL
Compound: 114
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Anti-inflammatory activity in LPS induced mouse RAW264.7 cells assessed as inhibition of NO production
Anti-inflammatory activity in LPS induced mouse RAW264.7 cells assessed as inhibition of NO production
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[PMID: 32688203] |
Chemical Information
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CAS No. 1039431-94-1
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Masse moléculaire 506.59
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Formule C30H34O7
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SMILES
O[C@@]1(C[C@](C(CC2)=C)([H])[C@@]3([H])[C@](OC4=O)([H])[C@]2([H])C4=C)[C@](CC[C@@]13O)(C5=O)[C@]([C@@](C6=C)([H])C5)([H])[C@](OC7=O)([H])[C@](CC6)([H])C7=C
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ainsliadimer A Related Classifications
HY-N12478 Related Classifications
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