AMG8380
AMG8380, an orally active and less active enantiomer of AMG8379, can serves as a negative control. AMG8380 inhibits human and mouse voltage-gated sodium channel NaV1.7 with IC50s of 0.907 and 0.387 μM, respectively. AMG8380 blocks Tetrodotoxin (TTX)-sensitive native channels with an IC50 of 2560 nM.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 1642112-32-0
- Formule: C25H16ClF2N3O5S
- Masse moléculaire:543.93
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Protocole
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
hNav1.7 0.907 μM (IC50) |
mNav1.7 0.387 μM (IC50) |
In Vivo
-
Animal Model:C57Bl/6 male mice[1]
-
Dosage:100 mg/kg
-
Administration:oral
-
Result:Failed to show a statistically significant effect on scratching behavior.
Chemical Information
-
CAS No. 1642112-32-0
-
Masse moléculaire 543.93
-
Formule C25H16ClF2N3O5S
-
SMILES
O=S(NC1=NOC=C1)(C2=CC(C=CC(N3C4=CC(F)=C(C=C4OC)C5=CC(Cl)=CC(F)=C5)=O)=C3C=C2)=O.[R]
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AMG8380 Related Classifications
HY-108425A Related Classifications
Powered by Bioz