Anticancer agent 231
Anticancer agent 231 (Compound P5) is a tyrosine protein kinase inhibitor with a IC50 value of 3.95 μM. Anticancer agent 231 inhibits the cell viability, cell proliferation, cell migration and cancer dryness of triple negative breast cancer (TNBC) cells by targeting EGFR-ERK 1/2 signaling pathway, and is expected to play an important role in the field of TNBC disease therapy.
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- CAS No.: 128519-30-2
- Formule: C23H22ClN3
- Masse moléculaire:375.89
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Stockage:
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Activité biologique
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Chemical Information
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Activité biologique
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ERK1 |
ERK2 |
Anticancer agent 231 (Compound P5) has good cytotoxicity and inhibits TNBC cells’ viability[1]. Anticancer agent 231 (Compound P5) (1, 2, 4 μM, 14 days; 1, 2, 4 μM, 8 days) decreases the proliferation capacity of Hs578T cells and MDA MB-231 cells[1]. Anticancer agent 231 (Compound P5) (1, 2, 4 μM, 12 h) decreases the migration ability of Hs578T cells[1]. Anticancer agent 231 (Compound P5) (1, 2 μM) inhibits tumor stemness and enhances the sensitivity of TNBC cells to paclitaxel[1]. Anticancer agent 231 (Compound P5) (1, 2, 4 μM; 5, 10, 20 μM) inhibits TNBC cells by targeting the EGFR-ERK 1/2 axis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:
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Concentration:
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Incubation Time:
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Result:
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Cell Line:Hs578T cell, MDA MB 231 cell
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Concentration:0-40 μM
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Incubation Time:48 h
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Result:Exhibited the most cytotoxic effect against Hs578T cells and MDA MB 231 cells
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Cell Line:Hs578T cell
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Concentration:1, 2, 4 μM
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Incubation Time:14 days
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Result:Inhibited the colony formation of Hs578T cells
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Cell Line:MDA MB 231 cell
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Concentration:5, 10, 20 μM
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Incubation Time:8 days
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Result:Inhibited the colony formation of MDA MB 231 cells
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Cell Line:Hs578T cell
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Concentration:1, 2, 4 μM
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Incubation Time:12 h
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Result:Inhibited the migration ability of Hs578T cells
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Cell Line:Hs578T cell, MDA MB 231 cell
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Concentration:1, 2, 4 μM; 5, 10, 20 μM
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Incubation Time:48 h
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Result:Reduced the EGFR expression level in Hs578T and MDA MB 231 cells and deactivated the EGFR in MDA MB 231 cells
Chemical Information
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CAS No. 128519-30-2
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Masse moléculaire 375.89
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Formule C23H22ClN3
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SMILES
ClC1=CC=C(C2=NN(C3=CC=CC=C3)C(C4=CC=C(N(C)C)C=C4)C2)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 231 Related Classifications
HY-162575 Related Classifications
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