Anticancer agent 345
Anticancer agent 345 is a heterobifunctional anticancer compound that exhibits weak antiproliferative activity against both ERα-overexpressing and non-overexpressing T-Rex 293 cells. Anticancer agent 345 can be used in cancer-related research.
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- CAS No.: 3099598-25-8
- Formule: C54H57N7O3S
- Masse moléculaire:884.14
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
ERα |
In Vitro
Anticancer agent 345 (III-154) exhibits moderate antiproliferative activity against MCF7 cells (GI50 = 0.0-0.5 μM)[1].
Anticancer agent 345 exhibits weak antiproliferative activity against both estrogen receptor α-overexpressing and non-overexpressing T-Rex 293 cells induced by Doxorubicin (HY-15142A) (GI50 > 2.5 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 3099598-25-8
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Masse moléculaire 884.14
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Formule C54H57N7O3S
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SMILES
CC1=C(C)SC2=C1C(C3=CC=C(N4CCC(O)(CC4)CC5CCN(C6=CC=C([C@@H]7C8=CC=C(O)C=C8CC[C@@H]7C9=CC=CC=C9)C=C6)CC5)C=C3)=N[C@H](CC%10=NC=CO%10)C%11=NN=C(C)N2%11
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 345 Related Classifications
HY-184953 Related Classifications
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