AO-022
AO-022 is a potent TALDO1 allosteric inhibitor. AO-022 decreases the expression of vimentin and snail. AO-022 shows antiproliferative activity and antitumor activity. AO-022 has the potential for the research of breast cancer.
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- Formule: C21H16ClNO4S
- Masse moléculaire:413.87
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
TALDO1[1]
AO-022 (5, 10, 20, 40, 80 µM; 24 h) inhibits cell viability in a dose-dependent manner in MDA-MB-231 cells[1].
AO-022 (0, 2.5,5, 10, 20 µM; 24 h) decreases the protein expression of vimentin and snail in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 cells
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Concentration:0, 2.5,5, 10, 20 µM
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Incubation Time:24 h
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Result:Inhibited the protein expression of vimentin and snail in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-week-old female nude mice (MDA-MB-231 cells)[1]
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Dosage:50 mg/kg
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Administration:I.p.; every other day for fourteen days
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Result:Significantly reduced tumor volume and tumor weight.
Chemical Information
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Masse moléculaire 413.87
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Formule C21H16ClNO4S
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SMILES
O=C1N(CC2=CC=CS2)C3=C(C=C(Cl)C=C3)[C@]1(O)CC(C4=CC=CC=C4O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Xu G, Huang R, Wumaier R, Lyu J, Huang M, Zhang Y, Chen Q, Liu W, Tao M, Li J, Tao Z, Yu B, Xu E, Wang L, Yu G, Gires O, Zhou L, Zhu W, Ding C, Wang H. Proteomic Profiling of Serum Extracellular Vesicles Identifies Diagnostic Signatures and Therapeutic Targets in Breast Cancer. Cancer Res. 2024 Jun 20. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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