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Cat. No.: HY-179354

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AP21998

AP21998 is a Fv (mutant FKBP) domain-selective ligand that binds to a single FKBPv. AP21998 disrupts FKBP-mediated oligomerization, blocks the proliferation of transformed myeloid progenitors and facilitates their terminal myeloid differentiation. AP21998 disrupts aggregates of CAD-hM1 receptor fusion protein, allowing receptors to exit the ER and enter the plasma membrane. AP21998 can be used for cancer research.

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CAS No.: 292606-90-7
Formule: C₄₃H₅₉N₃O₁₀
Masse moléculaire:777.94

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

AP21998 Chemical Structure

CAS No.: 292606-90-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

Chemical Information

CAS No. 292606-90-7
Masse moléculaire 777.94
Formule C₄₃H₅₉N₃O₁₀
SMILES

O=C(N1[C@@H](CCCC1)C(O[C@@H](C2=CC(OCC(NCCCN(C)C)=O)=CC=C2)CCC3=CC(OC)=C(C=C3)OC)=O)[C@H](C4=CC(OC)=C(C(OC)=C4)OC)CC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Sawyer GW, et al. Determination of the rate of muscarinic M1 receptor plasma membrane delivery using a regulated secretion/aggregation system. J Pharmacol Toxicol Methods. 2006 May-Jun;53(3):219-33. [Content Brief]

[2]. Lin CH, et al. Oligomeric self-association contributes to E2A-PBX1-mediated oncogenesis. Sci Rep. 2019 Mar 20;9(1):4915. [Content Brief]

[3]. Song GJ, et al. Regulated dimerization of the thyrotropin-releasing hormone receptor affects receptor trafficking but not signaling. Mol Endocrinol. 2005 Nov;19(11):2859-70. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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