ASP9436
ASP9436 is an orally active and blood-brain barrier permeable PDE10A inhibitor with an IC50 of 8 nM against human PDE10A. ASP9436 attenuates locomotor activity in mouse hyperactivity models and ameliorates visual recognition memory impairment in neonatal mice. ASP9436 is applicable to research related to schizophrenia.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 1401807-89-3
- Formule: C25H25Cl2N5O2
- Masse moléculaire:498.40
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
|
human PDE 10A 8 nM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:ICR mice aged 5-
6 weeks, PCP (2.5 mg/10 mL/kg, sc))-induced hyper-locomotion; Three-day-old male ddY mice PCP (15 mg/kg)-induced hyper-locomotion[1] -
Dosage:1, 3, 10, 30 mg/kg;0.0001, 0.0003, 0.001, 0.003 mg/kg (Neonatal mouse)
-
Administration:p.o., single administration
-
Result:Attenuated locomotor activityn, with an ED50 of 7.0 mg/kg.
Improved visual-recognition memory impairment in neonatal PCP-treated mice by the oral administration at 0.001 and 0.003 mg/kg in a novel object
recognition test (NORT).
Chemical Information
-
CAS No. 1401807-89-3
-
Masse moléculaire 498.40
-
Formule C25H25Cl2N5O2
-
SMILES
O=C1C=CC(C2=CN(C)N=C2COC3=CC=C(C4=CC=CC5=C4N=CN5C)C=C3)=CN1C.Cl.Cl
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ASP9436 Related Classifications
HY-120291 Related Classifications
Powered by Bioz