Boxidine
Boxidine is an orally active DHCR7 inhibitor. Boxidine inhibits DHCR7, blocks the conversion of 7-Dehydrocholesterol (HY-113279) to Cholesterol (HY-N0322), reduces serum cholesterol levels, causes accumulation of 7-dehydrocholesterol in serum and tissues, and inhibits sterol absorption. Boxidine exhibits antiproliferative and anticancer activities, with marginal activity against mouse tumors. Boxidine can be used in research related to diseases such as tumors and adrenal cancer.
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- CAS No.: 10355-14-3
- Formule: C19H20F3NO
- Masse moléculaire:335.37
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
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DHCR7 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 10355-14-3
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Masse moléculaire 335.37
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Formule C19H20F3NO
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SMILES
FC(F)(F)C1=CC=C(C=C1)C=2C=CC(OCCN3CCCC3)=CC2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Gailani S, et al. Effects of boxidine on human serum sterols and neoplasms. Clin Pharmacol Ther. 1972;13(1):91-96. [Content Brief]
[2]. Dalenc F, et al. Dendrogenin A: A Mammalian Metabolite of Cholesterol with Tumor Suppressor and Neurostimulating Properties. Current medicinal chemistry. 2015;22(30):3533-49. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Boxidine Related Classifications
HY-W726633 Related Classifications
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