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Cat. No.: HY-15774

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CBB1003

CBB1003 is a novel histone demethylase LSD1 inhibitor with IC50 of 10.

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CAS No.: 1379573-88-2
Formule: C₂₅H₃₁N₉O₄
Masse moléculaire:521.57

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

CBB1003 Chemical Structure

CAS No.: 1379573-88-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

CBB1003 is a novel histone demethylase LSD1 inhibitor with IC50 of 10.54 uM. IC50 value: 10.54 uM [1] Target: LSD1 inhibitor in vitro: Treatment of F9 cells with CBB1003 led to the activation of CHRM4 and SCN3A expression. Treatment of CBB1003 led to significant growth inhibition of mouse embryonic teratocarcinoma F9 cells. Treatment of mouse ES cells with CBB1003 and 1007 also led to substantial inhibition of the spherical growth of ES cells [1]. CBB1003 inhibited CRC cell proliferation and colony formation. In cultured CRC cells, inhibiting LSD1 activity by CBB1003 caused a decrease in LGR5 levels while overexpression of LGR5 reduced CBB1003-induced cell death [2].

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Chemical Information

CAS No. 1379573-88-2
Masse moléculaire 521.57
Formule C₂₅H₃₁N₉O₄
SMILES

NC(N1CCN(CC2=CC(C(N3CCN(C(C4=CC=C(C(N)=N)C=C4)=O)CC3)=O)=CC([N+]([O-])=O)=C2)CC1)=N
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Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Wang J, et al. Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties. Cancer Res. 2011 Dec 1;71(23):7238-49. [Content Brief]

[2]. Hsu HC, et al. CBB1003, a lysine-specific demethylase 1 inhibitor, suppresses colorectal cancer cells growth through down-regulation of leucine-rich repeat-containing G-protein-coupled receptor 5 expression. J Cancer Res Clin Oncol. 2014 Jul 25. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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CBB1003

Voir tous les produits spécifiques à Isoform Histone Demethylase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

CBB1003 Related Classifications

HY-15774 Related Classifications