CDK12-IN-9
CDK12-IN-9 is a potent and selective CDK12 inhibitor with an IC50 of 2.2 nM. CDK12-IN-9 inhibits pSER2 (a downstream marker of CDK12/13 activity). CDK12-IN-9 can be used for the research of cancer.
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- CAS No.: 3024723-74-5
- Formule: C23H20F2N10
- Masse moléculaire:474.47
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
CDK12 2.2 nM (IC50) |
CDK13 13 nM (IC50) |
CDK9 466 nM (IC50) |
CDK2 551 nM (IC50) |
CDK7 1491 nM (IC50) |
In Vitro
CDK12-IN-9 (Compound 17) potently inhibits purified CDK12 kinase with an IC50 of 2.2 ± 0.74 nM[1].
CDK12-IN-9 inhibits purified CDK13, CD9, CD7 and CD2 kinase with IC50 values of 13, 466, 1491 and 551 nM[1].
CDK12-IN-9 inhibits cellular pSER2 (a downstream marker of CDK12/13 activity) with an IC50 of 17 ± 4.1 nM[1].
CDK12-IN-9 inhibits pSER2 activity in whole blood with an IC50 of 209 ± 106 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Parmacokinetics
Chemical Information
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CAS No. 3024723-74-5
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Masse moléculaire 474.47
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Formule C23H20F2N10
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SMILES
N#CC1=CC2=C(N(C=N2)[C@H]3CCC[C@H](C3)NC4=NC=C(C(C5=CN(N=C5)CC(F)F)=N4)C#N)N=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDK12-IN-9 Related Classifications
HY-181645 Related Classifications
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