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Cat. No.: HY-124199

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Cephalochromin

Cephalochromin is an antibiotic and an inhibitor for bacterial fatty acid synthase (FabI). Cephalochromin inhibits FabI of Staphylococcus aureus and Escherichia coli with IC₅₀ of 1.9 and 1.8 μM. Cephalochromin inhibits gram-positive methicillin-resistant S. aureus (MRSA) and quinolone-resistant S. aureus (QRSA), with MIC of 2-8 µg/mL.

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CAS No.: 25908-26-3
Formule: C₂₈H₂₂O₁₀
Masse moléculaire:518.47

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

Cephalochromin Chemical Structure

CAS No.: 25908-26-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
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- Cellular Effect
Chemical Information
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Activité biologique

Description

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Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	2.72 μM Compound: Cephalochromin	Cytotoxicity against human A549 cells after 48 hrs by SRB assay Cytotoxicity against human A549 cells after 48 hrs by SRB assay	[PMID: 24588135]
A549	IC₅₀	5.22 μM Compound: Cephalochromin	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 24588135]
BHK-21	IC₅₀	20 μM Compound: Cephalochromin	Antagonist activity at human glucagon receptor expressed in BHK21 cells assessed as inhibition of glucagon-induced cAMP elevation by RIA Antagonist activity at human glucagon receptor expressed in BHK21 cells assessed as inhibition of glucagon-induced cAMP elevation by RIA	[PMID: 15387654]
Caco-2	IC₅₀	12.4 μM Compound: Cephalochromin	Cytotoxicity against human Caco2 cells after 48 hrs by MTT assay Cytotoxicity against human Caco2 cells after 48 hrs by MTT assay	[PMID: 24588135]
Hep 3B2	IC₅₀	14.31 μM Compound: Cephalochromin	Cytotoxicity against human Hep3B cells after 48 hrs by MTT assay Cytotoxicity against human Hep3B cells after 48 hrs by MTT assay	[PMID: 24588135]
HT-1080	IC₅₀	4.98 μM Compound: Cephalochromin	Cytotoxicity against human HT1080 cells after 48 hrs by MTT assay Cytotoxicity against human HT1080 cells after 48 hrs by MTT assay	[PMID: 24588135]
Huh-7	IC₅₀	4.64 μM Compound: Cephalochromin	Cytotoxicity against human HuH7 cells after 48 hrs by MTT assay Cytotoxicity against human HuH7 cells after 48 hrs by MTT assay	[PMID: 24588135]
SW1353	IC₅₀	3.54 μM Compound: Cephalochromin	Cytotoxicity against human SW1353 cells after 48 hrs by MTT assay Cytotoxicity against human SW1353 cells after 48 hrs by MTT assay	[PMID: 24588135]

Chemical Information

CAS No. 25908-26-3
Masse moléculaire 518.47
Formule C₂₈H₂₂O₁₀
SMILES

OC(C(C(C=C1O[C@@H](C2)C)=[C@@](C(O)=C3)[C@@](C(O)=C4)=C(C=C5O[C@@H](C6)C)C(C(O)=C5C6=O)=C4O)=C3O)=C1C2=O
Structure Classification
- Antibiotics
- Other Antibiotics
Initial Source
- Microorganisms
Cephalosporium caerulens
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zheng CJ, et al., Cephalochromin, a FabI-directed antibacterial of microbial origin. Biochem Biophys Res Commun. 2007 Nov 3;362(4):1107-12. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Cephalochromin

Voir tous les produits spécifiques à Isoform Antibiotic

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Cephalochromin Related Classifications

HY-124199 Related Classifications