Chloropyramine
Chloropyramine is competitive reversible H1 receptor antagonist. Chloropyramine also has anti-tumour activity in breast cancer. Chloropyramine can be used for the research of allergic conditions, such as conjunctivitis and bronchial asthma.
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- CAS No.: 59-32-5
- Formule: C16H20ClN3
- Masse moléculaire:289.80
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[1]|
H1 Receptor |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF-10A | IC50 |
>60 μM
Compound: 1
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Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
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[PMID: 35569251] |
| MDA-MB-157 | IC50 |
43.06 μM
Compound: 1
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Antiproliferative activity against human MDA-MB-157 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-157 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
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[PMID: 35569251] |
| MDA-MB-231 | IC50 |
49.73 μM
Compound: 1
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
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[PMID: 35569251] |
| MDA-MB-453 | IC50 |
>60 μM
Compound: 1
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Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
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[PMID: 35569251] |
In Vitro
Chloropyramine (25, 50 μM; 24 h, 48 h) induces SASH1 expression and apoptosis in breast cancer cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Breast cancer cell lines
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Concentration:25 or 50 μM
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Incubation Time:24 h
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Result:Increased SASH1 expression in breast cancer cell lines.
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Cell Line:T47D, MDA-MB-231 and BT-54 cells
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Concentration:50 μM
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Incubation Time:48 h
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Result:Induced apoptosis in breast cancer cell lines.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats[2]
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Dosage:10 mg/kg
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Administration:Intraperitoneal
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Result:Reduced histamine-induced hypothermia.
Chemical Information
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CAS No. 59-32-5
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Masse moléculaire 289.80
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Formule C16H20ClN3
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SMILES
CN(CCN(C1=CC=CC=N1)CC2=CC=C(Cl)C=C2)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Chloropyramine Related Classifications
HY-119995 Related Classifications
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