Crobenetine
Crobenetine (BIII-890), a benzomorphan derivative, is a potent, selective, and highly use-dependent Na+ channel blocker. Crobenetine displaces [3H]BTX from site 2 of the Na+ channel (IC50=49 nM) in rat brain synaptosomes, yet exhibits only low binding affinity for other receptors and ion channels. Crobenetine protects brain tissue from the deleterious effects of focal cerebral ischemia in rodents.
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- CAS No.: 221019-25-6
- Formule: C25H33NO2
- Masse moléculaire:379.54
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 221019-25-6
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Masse moléculaire 379.54
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Formule C25H33NO2
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SMILES
OC1=C2C([C@]3(C)CCN(C[C@@H](OCC4=CC=CC=C4)C)[C@](C3(C)C)([H])C2)=CC=C1
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Synonyms
BIII-890; BIII-890 CL free acid
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Crobenetine Related Classifications
HY-16923 Related Classifications
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