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CU-CPT 4a

(Synonyms: TLR3-IN-1)
13 Cited Publications
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Based on 13 publication(s) in Google Scholar

CU-CPT 4a (TLR3-IN-1) is a potent, highly selective TLR3 signaling inhibitor. CU-CPT 4a represses the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β.

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  • Pureté: 99.50%
  • CAS No.: 1279713-77-7
  • Formule: C18H13ClFNO3S
  • Masse moléculaire:377.82
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • CU-CPT 4a Chemical Structure
    CU-CPT 4a Chemical Structure
  • Experimental Validation Results for CU-CPT 4a
  • Experimental Validation Results for CU-CPT 4a
  • Experimental Validation Results for CU-CPT 4a
  • Experimental Validation Results for CU-CPT 4a
  • Experimental Validation Results for CU-CPT 4a
  • Experimental Validation Results for CU-CPT 4a
  • Experimental Validation Results for CU-CPT 4a
  • Experimental Validation Results for CU-CPT 4a
CAS No.: 1279713-77-7
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  • CU-CPT 4a Chemical Structure
    CU-CPT 4a Chemical Structure
    1/16
  • 1/16

    CU-CPT 4a purchased from MedChemExpress. Usage Cited in: J Extracell Vesicles. 2025 May;14(5):e70083. [Abstract]

    Customer Validation
     m6A levels in EVs regulate inflammatory responses via TLR8 in macrophages. Differentiated THP‐1 cells (dTHP‐1) were pretreated with or without CU‐CPT‐9a (HY-112667; 48 h) and CU‐CPT‐4a (HY-108473; 48 h). Whole‐cell lysates obtained from dTHP‐1 cells were subjected to Western blot analysis using an anti‐phospho p65 antibody, anti‐p65 antibody and anti‐β‐actin antibody. Representative images from three independent experiments are shown.

  • 1/16

    CU-CPT 4a purchased from MedChemExpress. Usage Cited in: J Extracell Vesicles. 2025 May;14(5):e70083. [Abstract]

    Customer Validation
     m6A levels in EVs regulate inflammatory responses via TLR8 in macrophages. Differentiated THP‐1 cells (dTHP‐1) were pretreated with or without CU‐CPT‐9a (HY-112667; 48 h) and CU‐CPT‐4a (HY-108473; 48 h). Conditioned medium from dTHP‐1 cells treated with CCD‐841‐CoN or HT29 small EVs was used for ELISA. dTHP‐1 cells were pre‐transfected with or without TLR8 siRNA.

  • 1/16

    CU-CPT 4a purchased from MedChemExpress. Usage Cited in: Mol Pain. 2025 Jan-Dec:21:17448069251346373. [Abstract]

    Customer Validation
     TLR3 antagonist CU CPT4a inhibited NTG-induced mechanical allodynia. Repeated treatment with CU CPT4a (5 mg/kg, i.p.) or vehicle (equal volumes of DMSO) every other day before NTG injections for 9 days. Repeated treatment with CU CPT4a inhibited basal hind paw mechanical and periorbital mechanical allodynia.

  • 1/16

    CU-CPT 4a purchased from MedChemExpress. Usage Cited in: Mol Pain. 2025 Jan-Dec:21:17448069251346373. [Abstract]

    Customer Validation
     TLR3 antagonist CU CPT4a inhibited NTG-induced mechanical allodynia. Repeated treatment with CU CPT4a (5 mg/kg, i.p.) or vehicle (equal volumes of DMSO) every other day before NTG injections for 9 days. Post-treatment responses, including hind paw mechanical and periorbital mechanical allodynia, were estimated 2 h after NTG administration.

  • 1/16

    CU-CPT 4a purchased from MedChemExpress. Usage Cited in: Mol Pain. 2025 Jan-Dec:21:17448069251346373. [Abstract]

    Customer Validation
     TLR3 antagonist CU CPT4a (5 mg/kg; i.p.; every other day for 9 days before NTG injection) reduced the expression of TLR3 in TNC. Quantitative analysis of the number of TLR3+Neuron in the TNC in a 212 × 212 µm² visual field of each section per mouse after NTG injection.

  • 1/16

    CU-CPT 4a purchased from MedChemExpress. Usage Cited in: Mol Pain. 2025 Jan-Dec:21:17448069251346373. [Abstract]

    Customer Validation
     TLR3 antagonist CU CPT4a (5 mg/kg; i.p.; every other day for 9 days before NTG injection) reduced the expression of TLR3 in TNC. Immunoblot analysis of TLR3 (n = 5).

  • 1/16

    CU-CPT 4a purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Nov 3;14(1):7048. [Abstract]

    Customer Validation
     Immunofluorescence images of MMP21 in the absence or presence of RIG012 or CU-CPT 4a. β-cat ΔN/RasV12 cells were mixed with β-cat ΔN cells in the presence of BFA, and were treated with DMSO, 2.5 μM RIG012 or 50 μM CU-CPT 4a. Cells were stained with Hoechst 33342 (blue) and anti-MMP21 antibody (white).

  • 1/16

    CU-CPT 4a purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Nov 3;14(1):7048. [Abstract]

    Customer Validation
     Immunofluorescence images of MMP21 or p65 in intestinal organoids from APCMin-Villin-RasV12 mice in the absence or presence of 10 μM RIG012 or 100 μM CU-CPT 4a.

  • CU-CPT 4a