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Cat. No.: HY-122115

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DCE_42

DCE_42 is a potent EZH2 inhibitor with an IC₅₀ value of 22.6 µM. DCE_42 inhibits cell proliferation and has the potential for the research of lymphoma.

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CAS No.: 669749-45-5
Formule: C₂₂H₁₉N₉O₂S
Masse moléculaire:473.51

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

DCE_42 Chemical Structure

CAS No.: 669749-45-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

DCE_42 is a potent EZH2 inhibitor with an IC₅₀ value of 22.6 µM. DCE_42 inhibits cell proliferation and has the potential for the research of lymphoma^[1].

IC₅₀ & Target^[1]

EZH2

22.6 μM (IC₅₀)

Voir tous les produits spécifiques à Isoform Histone Methyltransferase :

Cellular Effect

Cell Line	Type	Value	Description	References
DB	IC₅₀	32.8 μM Compound: DCE_42	Antiproliferative activity against human DB cells expressing EZH2 mutant assessed as growth inhibition measured after 72 hrs by AlamaBlue assay Antiproliferative activity against human DB cells expressing EZH2 mutant assessed as growth inhibition measured after 72 hrs by AlamaBlue assay	[PMID: 27289323]
Toledo	IC₅₀	24.1 μM Compound: DCE_42	Antiproliferative activity against human Toledo cells expressing wild-type EZH2 assessed as growth inhibition measured after 72 hrs by AlamaBlue assay Antiproliferative activity against human Toledo cells expressing wild-type EZH2 assessed as growth inhibition measured after 72 hrs by AlamaBlue assay	[PMID: 27289323]

In Vitro

DCE_42 inhibits Toledo and DB cell proliferation with IC₅₀ values of 24.1, 32.8 µM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 669749-45-5
Masse moléculaire 473.51
Formule C₂₂H₁₉N₉O₂S
SMILES

O=C1NC(NC2=NC(C)=C3C=C(C=CC3=N2)OC)=NC(CSC4=NN=NN4C5=CC=CC=C5)=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Wu Y, et al. Identification of novel EZH2 inhibitors through pharmacophore-based virtual screening and biological assays. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3813-7. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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DCE_42

Voir tous les produits spécifiques à Isoform Histone Methyltransferase