Disulfamide
Disulfamide, an orally active diuretic, is a carbonic anhydrase inhibitor with the IC50 value of 0.07 μM. Disulfamide leads to diuresis by inhibiting carbonic anhydrase and preventing the reabsorption of sodium and bicarbonate in the proximal tubule.
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- CAS No.: 671-88-5
- Formule: C7H9ClN2O4S2
- Masse moléculaire:284.74
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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- Pureté et documentation
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Help & FAQs
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Methazolamide (Standard)Carbonic Anhydrase Inhibitor -
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Tioxolone (Standard)Carbonic Anhydrase Inhibitor -
HY-108316R
Sultiame (Standard)Carbonic Anhydrase Inhibitor
Activité biologique
Description
IC50 & Target
IC50: 0.07 μM (carbonic anhydrase)[1]
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats weighing between 200-300 g[2]
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Dosage:200 mg/kg
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Administration:Intraperitoneal injection; once
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Result:Resulted in elevated blood sugar levels from an initial blood glucose concentration of 143.1 mg/100 mL to a one hour later final concentration of 194.6 mg/100 mL, an increase of 36%.
Chemical Information
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CAS No. 671-88-5
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Masse moléculaire 284.74
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Formule C7H9ClN2O4S2
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SMILES
O=S(C1=C(C)C=C(Cl)C(S(=O)(N)=O)=C1)(N)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Disulfamide Related Classifications
HY-137364 Related Classifications
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