DU172
DU172 is a ligand for the adenosine A1 receptor (Adenosine A1 Receptor), with an IC50 of 24.9 nM against A1AR and an IC50 of 0.42 μM against A2AAR.
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- CAS No.: 321907-03-3
- Formule: C24H30FN5O5S
- Masse moléculaire:519.59
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
DU172 (Compound 23a) potently binds to the A1 adenosine receptor on the cell membrane of DDT1 MF-2, with an IC50 of 24.9 nM for inhibiting [3H]DPCPX binding[2].
DU172 binds to the A2A adenosine receptor on the membrane of PC-12 cells, with an IC50 of 0.42 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 321907-03-3
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Masse moléculaire 519.59
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Formule C24H30FN5O5S
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SMILES
O=C(NCCCN1C(=O)N(C(=O)C=2NC(=NC21)C3CCCCC3)CCC)C4=CC=C(C=C4)S(=O)(=O)F
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Glukhova A, et al. Structure of the Adenosine A1 Receptor Reveals the Basis for Subtype Selectivity. Cell. 2017;168(5):867-877.e13. [Content Brief]
[2]. Beauglehole AR, et al. Fluorosulfonyl-substituted xanthines as selective irreversible antagonists for the A(1)-adenosine receptor. J Med Chem. 2000;43(26):4973-4980. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DU172 Related Classifications
HY-165509 Related Classifications
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