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Cat. No.: HY-P99930

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Biologically Validated

Efruxifermin

(Synonyms: AKR-001; AMG-876)

2 Cited Publications

Avis client

Based on 2 publication(s) in Google Scholar

Efruxifermin is an Fc-FGF21 fusion protein (human IgG1 Fc domain linked to a modified human FGF21). Efruxifermin has prolonged half-life and enhanced receptor affinity compared with native human FGF21. Efruxifermin can be used for the research of non-alcoholic steatohepatitis.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté: 98.58%
CAS No.: 2375240-92-7
Masse moléculaire:91.863 kDa

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Efruxifermin Chemical Structure

CAS No.: 2375240-92-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Species Reactivity
- IC₅₀ & Target
- In Vivo
- Essai clinique
- Conjugated
- Reconsititution
- Format
- Verified Bioactivity
Chemical Information
Publications (2)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Species Reactivity

Human

IC₅₀ & Target

FGFR1

In Vivo

Efruxifermin (0-100 mg/kg, SC, Once weekly, for 4 or 26 weeks) reduces body weight gain of Sprague Dawley rats in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male and female Sprague Dawley rats^[1]
Dosage:

0, 1, 10, 30, 100 mg/kg
Administration:

Subcutaneous injection, Once weekly, for 4 or 26 weeks
Result:

Significantly reduced body weight gain after 4 and 26 weeks, despite increasing food intake. Markers of sympathetic activation, urinary corticosterone and ratio of adrenal-to-body weight were unchanged.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

IGHG1 Fc (Fragment constant)-[FGF21 (fibroblast growth factor 21)]2

Verified Bioactivity

Loaded Efruxifermin on Protein A Chip, can bind Klotho beta Protein, Human (HEK293, His, HY-P77972) with an affinity constant of 2.21E-08 M as determined in SPR assay.

Chemical Information

CAS No. 2375240-92-7
Appearance Liquid
Masse moléculaire 91.863 kDa
Color Colorless to light yellow
SMILES

[Efruxifermin]
Synonyms

AKR-001; AMG-876
Livraison

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

All IFIn Vivo Efficacy StudyHistological Imaging/StainingRT-PCRWB

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Journal Impact Factor

J Adv Res

FGF21-FGFR1 signaling protects against cardiac hypertrophy by regulating PINK1-mediated mitophagy pathway. [Abstract]

2025 Oct 29:S2090-1232(25)00848-3. PMID: 41173187

Efruxifermin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Oct 29:S2090-1232(25)00848-3. [Abstract]

Efruxifermin (FGF21; 1 mg/kg; subcutaneous injection). Measurement of LVEF in the indicated groups.

Efruxifermin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Oct 29:S2090-1232(25)00848-3. [Abstract]

Efruxifermin (FGF21; 1 mg/kg; subcutaneous injection). Representative image of HE staining.

Efruxifermin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Oct 29:S2090-1232(25)00848-3. [Abstract]

Efruxifermin (FGF21; 1 mg/kg; subcutaneous injection). ANP and BNP mRNA levels in the indicated group.

Efruxifermin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Oct 29:S2090-1232(25)00848-3. [Abstract]

Efruxifermin (FGF21; 1 mg/kg; subcutaneous injection). ANP and BNP protein levels in the indicated group.
Research (Wash D C)

Fibroblast Growth Factor 21 Promotes Vascular Smooth Muscle Cell Contractile Polarization via p38 Mitogen-Activated Protein Kinase-Promoted Serum Response Factor Phosphorylation. [Abstract]

2025 Aug 5:8:0815. PMID: 40765997

Efruxifermin purchased from MedChemExpress. Usage Cited in: Research (Wash D C). 2025 Aug 5:8:0815. [Abstract]

Efruxifermin (5 mg/kg; subcutaneous injection). The expression of SMA and OPN in SMA-positive cells in neointimal areas was determined by immunofluorescence staining.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (260 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Références

[1]. Tillman EJ, et al. Efruxifermin, a long-acting Fc-fusion FGF21 analogue, reduces body weight gain but does not increase sympathetic tone or urine volume in Sprague Dawley rats. Br J Pharmacol. 2022 Apr;179(7):1384-1394. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Efruxifermin

2 Cited Publications

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Activité biologique
- Description
- Species Reactivity
- IC₅₀ & Target
- In Vivo
- Essai clinique
- Conjugated
- Reconsititution
- Format
- Biological Activity
Chemical Information
Publications (2)
Pureté et documentation
Références

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Efruxifermin

Antibody Inhibitor Library

Publications Citing Use of MedChemExpress (MCE) Efruxifermin

Activité biologique

Chemical Information

Publications (2)

Pureté et documentation

Références

Calculators

Help & FAQs

Efruxifermin

Protein A Agarose

HOLO Human Interleukin-2 (IL-2) Detection Kit

Bradford Protein Assay Kit

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

Antibody Inhibitor Library

Publications Citing Use of MedChemExpress (MCE) Efruxifermin

Activité biologique

Chemical Information

Publications (2)

Pureté et documentation

Références

Calculators

Help & FAQs

Efruxifermin Related Classifications

HY-P99930 Related Classifications