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Cat. No.: HY-107054

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ESP-31015

Name: ESP-31015
Brand: MedChemExpress
SKU: HY-107054
Availability: PreOrder

(Synonyms: ETC-1001)

ESP-31015 (ETC-1001) is an orally active and non-fibrate based PPARα agonists. ESP-31015 demonstrates significant lipid-regulating effects in the obese Zucker rat model. ESP-31015 can be used in cardiovascular disease research.

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CAS No.: 413624-55-2
Formule: C₁₇H₃₄O₃
Masse moléculaire:286.45

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

ESP-31015 Chemical Structure

CAS No.: 413624-55-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

^[1]

PPARα

Voir tous les produits spécifiques à Isoform PPAR :

Cellular Effect

Cell Line	Type	Value	Description	References
Hepatocyte	IC₅₀	1.5 μM Compound: 39	Inhibition of lipid synthesis in primary rat hepatocytes by incorporation radiolabeled acetate into cellular lipids Inhibition of lipid synthesis in primary rat hepatocytes by incorporation radiolabeled acetate into cellular lipids	[PMID: 16392818]
Hepatocyte	IC₅₀	4 μM Compound: 14c	Concentration required for inhibition of lipid synthesis in primary cultures of rat hepatocytes Concentration required for inhibition of lipid synthesis in primary cultures of rat hepatocytes	[PMID: 15537362]

In Vivo

ESP-31015 (100 mg/kg, p.o., once daily for 2 weeks) shows a 34.6% increase in serum HDL-cholesterol and a 71% reduction in serum triglycerides in female obese Zucker fatty rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female obese Zucker fatty rats model^[1]
Dosage:

100 mg/kg
Administration:

Oral administration (p.o.), once daily for 2 weeks
Result:

Showed a 34.6% increase in serum HDL-cholesterol and a 71% reduction in serum triglycerides.

Chemical Information

CAS No. 413624-55-2
Masse moléculaire 286.45
Formule C₁₇H₃₄O₃
SMILES

OCC(C)(C)CCCCC(CCCCC(C)(C)CO)=O
Synonyms

ETC-1001
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Pal M, et al. HDL elevators and mimetics--emerging therapies for atherosclerosis. Cardiovasc Hematol Agents Med Chem. 2007 Jan;5(1):55-66. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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