IL10RA - interleukin 10 receptor subunit alpha Gene

Also Known as CD210; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3587

About IL10RA

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:117,986,394-118,003,037 (from NCBI)

This gene has 12 transcripts (splice variants), 240 orthologues, 11 paralogues and is associated with 2 phenotypes. Broad expression in spleen (RPKM 29.9), bone marrow (RPKM 20.8) and 18 other tissues.

Summary

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the Insulin Receptor substrate-2/PI 3-kinase/Akt pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and Tyk2 kinases. Two transcript variants, one protein-coding and the Other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]

IL10RA Products (1)

mRNA	Protein	Name
NM_001558.4	NP_001549.2	interleukin-10 receptor subunit alpha precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables interleukin-10 receptor activity	IDA IDA: Inferred from direct assay	16982608	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11485736	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in interleukin-10-mediated signaling pathway	IDA IDA: Inferred from direct assay	16982608	GOA
involved in intestinal epithelial structure maintenance	IDA IDA: Inferred from direct assay	29454749	GOA
involved in negative regulation of autophagy	IDA IDA: Inferred from direct assay	26962683	GOA
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	24367025	GOA
involved in positive regulation of receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	16982608	GOA
involved in ubiquitin-dependent endocytosis	IDA IDA: Inferred from direct assay	22087322	GOA

Cellular Component GO Annotation	Evidence	Références	Source
is active in apical plasma membrane	IDA IDA: Inferred from direct assay	22087322	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	22087322	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL10RA Protein Structure

Tissue_fac

0
100
200
300
400
500
578 a.a.

Protein Preferred Names	Protein Names
interleukin-10 receptor subunit alpha	IL-10 receptor subunit alpha

IL10RA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	IL10RA	Q13651	SLC38A7	Homo sapiens	Q9NVC3	Validated Y2H	32296183
Intra	IL10RA	Q13651	TMEM242	Homo sapiens	Q9NWH2	Validated Y2H	32296183
Intra	IL10RA	Q13651	IL10	Homo sapiens	P22301	ITC	15837194
Intra	IL10RA	Q13651	IL10	Homo sapiens	P22301	SPR	15837194
Intra	IL10RA	Q13651	IL10	Homo sapiens	P22301	SPR	12513909
Intra	IL10RA	Q13651	PLPP6	Homo sapiens	Q8IY26	Validated Y2H	32296183
Intra	IL10RA	Q13651	C1QL4	Homo sapiens	Q86Z23	Validated Y2H	32296183
Intra	IL10RA	Q13651	CD302	Homo sapiens	Q8IX05	Validated Y2H	32296183
Intra	IL10RA	Q13651	TMUB2	Homo sapiens	Q71RG4	Validated Y2H	32296183
Intra	IL10RA	Q13651	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	IL10RA	Q13651	BTRC	Homo sapiens	Q9Y297	Anti Tag CoIP	22087322
Intra	IL10RA	Q13651	BTRC	Homo sapiens	Q9Y297	Validated Y2H	32296183
Intra	IL10RA	Q13651	SLC66A2	Homo sapiens	Q8N2U9	Validated Y2H	32296183
Intra	IL10RA	Q13651	SLC7A14	Homo sapiens	Q8TBB6	Validated Y2H	32296183
Intra	IL10RA	Q13651	HACD2	Homo sapiens	Q6Y1H2	Validated Y2H	32296183
Intra	IL10RA	Q13651	CMTM3	Homo sapiens	Q96MX0	Validated Y2H	32296183
Intra	IL10RA	Q13651	YIPF6	Homo sapiens	Q96EC8	Validated Y2H	32296183
Intra	IL10RA	Q13651	RUSF1	Homo sapiens	Q96GQ5	Validated Y2H	32296183
Intra	IL10RA	Q13651	SMCO4	Homo sapiens	Q9NRQ5	Validated Y2H	32296183
Intra	IL10RA	Q13651	SLC30A2	Homo sapiens	Q9BRI3	Validated Y2H	32296183
Intra	IL10RA	Q13651	SELENOK	Homo sapiens	Q9Y6D0	Validated Y2H	32296183
Cross	IL10RA	Q13651	UL111A	Human cytomegalovirus	P17150	X-Ray Diffraction	12093920
Cross	IL10RA	Q13651	UL111A	Human cytomegalovirus	P17150	SPR	15837194
Cross	IL10RA	Q13651	NS	Influenza A virus	P03495	Y2H	24008843

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL10RA Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P70692	IL-10R alpha Protein, Human (HEK293, His)	Q13651 (H22-N235)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78464	IL-10R alpha Protein, Human (HEK293, His-Avi)	Q13651 (H22-N235)	≥ 95%, as determined by Bis-Tris PAGE.

IL10RA Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P84553	CD210 Antibody (YA4250)	ICC/IF, FC, ELISA	Human
HY-P84553A	CD210 Antibody (YA4250)(PBS only)	ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Inflammatory Bowel Disease 28, Autosomal Recessive	IBD28 Inflammatory Bowel Disease 28, Early Onset, Autosomal Recessive Inflammatory Bowel Disease, Early-Onset, Autosomal Recessive Early-Onset Autosomal Recessive Inflammatory Bowel Disease Bowel Disease, Inflammatory, Type 28, Autosomal Recessive
Inflammatory Bowel Disease 28	Early Onset Autosomal Recessive Inflammatory Bowel Disease 28 Ibd28 Inflammatory Bowel Disease 28, Autosomal Recessive
Inflammatory Bowel Disease 25, Autosomal Recessive	Immune Dysregulation-Inflammatory Bowel Disease-Arthritis-Recurrent Infections Syndrome IBD25 Inflammatory Bowel Disease 25, Early Onset, Autosomal Recessive Il10-Related Early-Onset Ibd Il10-Related Early-Onset Inflammatory Bowel Disease Inflammatory Bowel Disease, Early-Onset, Autosomal Recessive Autosomal Recessive Early-Onset Inflammatory Bowel Disease Autosomal Recessive Early-Onset Ibd Early-Onset Autosomal Recessive Inflammatory Bowel Disease Bowel Disease, Inflammatory, Type 25, Autosomal Recessive
Cytomegalovirus Retinitis	Cmv Retinitis
Colitis
Ulcerative Colitis	Colitis Gravis Left Sided Ulcerative Colitis Left-Sided Ulcerative Colitis Idiopathic Proctocolitis Inflammatory Bowel Disease, Ulcerative Colitis Type Uc Colitis Ulcerative Colitis, Ulcerative Chronic Left-Sided Ulcerative Colitis Uc - [Ulcerative Colitis] Chronic Ulcerative Enteritis Mucosal Proctocolitis Ulcerative Mucosal Proctocolitis Left Hemicolitis
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Visceral Leishmaniasis	Kala-Azar Leishmaniasis, Visceral Infection By Visceral Leishmaniasis Leishmaniasis Visceral Sahib Disease Ponos Burdwan Fever Mard El Bicha Sirkari Disease Indian Visceral Leishmaniasis Dumdum Fever Visceral Leishmaniasis Due To Leishmania Donovani
Gastrointestinal Defects And Immunodeficiency Syndrome 1	Familial Intestinal Polyatresia Syndrome Fipa Gastrointestinal Defects And Immunodeficiency Syndrome Multiple Gastrointestinal Atresias Familial Isolated Pituitary Adenoma Intestinal Atresia, Multiple Multiple Intestinal Atresia GIDID1 Multiple Intestinal Atresia And/Or Inflammatory Bowel Disease With Or Without Immunodeficiency Minat Gidid Meddra:10028210 Familial Isolated Pituitary Adenoma Syndrome Intestinal Atresia Multiple Combined Immunodeficiency-Enteropathy Spectrum Cid-Mia/Early-Onset Ibd Intestinal Atresia, Multiple And/Or Inflammatory Bowel Disease With Or Without Immunodeficiency Mia Gastrointestinal Defect And Immunodeficiency Syndrome Pituitary Adenoma Predisposition Pituitary Adenoma, Familial Isolated
Folliculitis
Lymphoproliferative Syndrome, X-Linked, 2	XLP2 Xiap Deficiency X-Linked Lymphoproliferative Syndrome 2 X-Linked Lymphoproliferative Disease Due To Xiap Deficiency Xiap-Related Lymphoproliferative Disease, X-Linked X-Linked Lymphoproliferative Syndrome Type 2 Xiap Deficiency Syndrome
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked	IPEX X-Linked Autoimmunity-Allergic Dysregulation Syndrome Xlaad Diarrhea, Polyendocrinopathy, Fatal Infection Syndrome, X-Linked Ipex Syndrome Insulin-Dependent Diabetes Mellitus Secretory Diarrhea Syndrome Iddm-Secretory Diarrhea Syndrome Dmsd Autoimmunity-Immunodeficiency Syndrome, X-Linked Enteropathy, Autoimmune, With Hemolytic Anemia And Polyendocrinopathy Xpid Diabetes Mellitus, Congenital Insulin-Dependent, With Fatal Secretory Diarrhea Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome Polyendocrinopathy, Immune Dysfunction, And Diarrhea, X-Linked Autoimmune Enteropathy Type 1 Immunodeficiency, Polyendocrinopathy, And Enteropathy, X-Linked Immunodeficiency, Polyendocrinopathy, And Enteropathy, X-Linked, Formerly Immunodeficiency, Polyendocrinopathy, Enteropathy X-Linked Syndrome Immunodysregulation, Polyendocrinopathy And Enteropathy X-Linked Autoimmunity-Immunodeficiency Syndrome X-Linked Iddm Secretory Diarrhea Syndrome Polyendocrinopathy, Immune Dysfunction And Diarrhea X-Linked Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome Immunodeficiency Polyendocrinopathy, Enteropathy, X-Linked Syndrome X-Linked Autoimmunity-Immunodeficiency Syndrome Immunodeficiency, Polyendocrinopathy, And Enteropathy X-Linked Syndrome X-Linked Syndrome Of Polyendocrinopathy, Immune Dysfunction, And Diarrhea
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Anal Fistula	Anorectal Fistula Rectal Fistula Allingham Ulcer Perianal Fistula Fistula In Ano Anorectum Fistula
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS06673	IL10RA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174645	Human IL10RA mRNA		/	Unkown
HY-RS17431	Il10ra Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23886	Il10ra Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P990776	Vimekofusp		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IL10RA	MGD	MGI:96538
Canis familiaris	IL10RA	VGNC	VGNC:41929
Macaca mulatta	IL10RA	VGNC	VGNC:73705
Felis catus	IL10RA	VGNC	VGNC:67753
Bos taurus	IL10RA	VGNC	VGNC:30107
Rattus norvegicus	IL10RA	RGD	RGD:620138
Others	IL10RA	NCBI