Gomisin M1
Based on 1 Customer Validation
Gomisin M1 ((±)-Gomisin M1) is a potent anti-HIV agent with an EC50 of <0.65 μM.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.75%
- CAS No.: 82467-50-3
- Formule: C22H26O6
- Masse moléculaire:386.44
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Stockage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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HIV-1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>10 μM
Compound: 11
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Cytotoxicity against human A549 cells after 3 days by MTT assay
Cytotoxicity against human A549 cells after 3 days by MTT assay
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[PMID: 23738539] |
| H9 | EC50 |
<0.65 μM
Compound: 4
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Antiviral activity against HIV1 3B in H9 cells after 4 days by p24-antigen ELISA
Antiviral activity against HIV1 3B in H9 cells after 4 days by p24-antigen ELISA
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[PMID: 17190445] |
| H9 | IC50 |
44.5 μM
Compound: 4
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Cytotoxicity against human H9 cells after 4 days
Cytotoxicity against human H9 cells after 4 days
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[PMID: 17190445] |
| HCT-116 | IC50 |
55.38 μM
Compound: GM
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Antiproliferative activity against human HCT-116 cells incubated for 24 hrs by alamar blue assay
Antiproliferative activity against human HCT-116 cells incubated for 24 hrs by alamar blue assay
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[PMID: 34038111] |
| HeLa | IC50 |
17.15 μM
Compound: GM
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Antiproliferative activity against human HeLa cells assessed as increase in miR-21 biogenesis level measured after 24 hrs by luciferase assay
Antiproliferative activity against human HeLa cells assessed as increase in miR-21 biogenesis level measured after 24 hrs by luciferase assay
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[PMID: 34038111] |
| HeLa | IC50 |
32.83 μM
Compound: GM
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Antiproliferative activity against human HeLa cells incubated for 24 hrs by alamar blue assay
Antiproliferative activity against human HeLa cells incubated for 24 hrs by alamar blue assay
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[PMID: 34038111] |
| HepG2 | IC50 |
27.26 μM
Compound: GM
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Antiproliferative activity against human HepG2 cells incubated for 24 hrs by alamar blue assay
Antiproliferative activity against human HepG2 cells incubated for 24 hrs by alamar blue assay
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[PMID: 34038111] |
| Huh-7 | IC50 |
32.23 μM
Compound: GM
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Antiproliferative activity against human Huh-7 cells incubated for 24 hrs by alamar blue assay
Antiproliferative activity against human Huh-7 cells incubated for 24 hrs by alamar blue assay
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[PMID: 34038111] |
| MCF7 | IC50 |
>10 μM
Compound: 11
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Cytotoxicity against human MCF7 cells after 3 days by MTT assay
Cytotoxicity against human MCF7 cells after 3 days by MTT assay
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[PMID: 23738539] |
| MDA-MB-231 | IC50 |
56.61 μM
Compound: GM
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Antiproliferative activity against human MDA-MB-231 cells incubated for 24 hrs by alamar blue assay
Antiproliferative activity against human MDA-MB-231 cells incubated for 24 hrs by alamar blue assay
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[PMID: 34038111] |
| MHCC97 | IC50 |
24.75 μM
Compound: GM
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Antiproliferative activity against human MHCC97 cells incubated for 24 hrs by alamar blue assay
Antiproliferative activity against human MHCC97 cells incubated for 24 hrs by alamar blue assay
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[PMID: 34038111] |
| NB-4 | IC50 |
>10 μM
Compound: 11
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Cytotoxicity against human NB4 cells after 3 days by MTT assay
Cytotoxicity against human NB4 cells after 3 days by MTT assay
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[PMID: 23738539] |
| PC-3 | IC50 |
>10 μM
Compound: 11
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Cytotoxicity against human PC3 cells after 3 days by MTT assay
Cytotoxicity against human PC3 cells after 3 days by MTT assay
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[PMID: 23738539] |
| SH-SY5Y | IC50 |
>10 μM
Compound: 11
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Cytotoxicity against human SH-SY5Y cells after 3 days by MTT assay
Cytotoxicity against human SH-SY5Y cells after 3 days by MTT assay
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[PMID: 23738539] |
| SK-HEP1 | IC50 |
20.56 μM
Compound: GM
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Antiproliferative activity against human SK-HEP1 cells incubated for 24 hrs by alamar blue assay
Antiproliferative activity against human SK-HEP1 cells incubated for 24 hrs by alamar blue assay
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[PMID: 34038111] |
Gomisin M1 ((±)-Gomisin M1) (4 days) shows anti-HIV-1 activity with an EC50 of <0.65 μM in H9 T cell lines and therapeutic index (TI) is >68[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 82467-50-3
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Appearance Solid
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Masse moléculaire 386.44
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Formule C22H26O6
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Color White to off-white
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SMILES
OC1=C(C2=C3C=C4OCOC4=C2OC)C(CC(C)C(C)C3)=CC(OC)=C1OC
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Synonyms
(±)-Gomisin M1
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvant et solubilité
DMSO : 17.2 mg/mL (44.51 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5877 mL | 12.9386 mL | 25.8772 mL | 64.6931 mL |
| 5 mM | 0.5175 mL | 2.5877 mL | 5.1754 mL | 12.9386 mL | |
| 10 mM | 0.2588 mL | 1.2939 mL | 2.5877 mL | 6.4693 mL | |
| 15 mM | 0.1725 mL | 0.8626 mL | 1.7251 mL | 4.3129 mL | |
| 20 mM | 0.1294 mL | 0.6469 mL | 1.2939 mL | 3.2347 mL | |
| 25 mM | 0.1035 mL | 0.5175 mL | 1.0351 mL | 2.5877 mL | |
| 30 mM | 0.0863 mL | 0.4313 mL | 0.8626 mL | 2.1564 mL | |
| 40 mM | 0.0647 mL | 0.3235 mL | 0.6469 mL | 1.6173 mL |
Gomisin M1 Related Classifications
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